Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1995-03-16
1999-11-16
Stucker, Jeffrey
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
435236, 4241931, 4242041, 4242061, A61K 9127, A61K 39385, A61K 3912, C12N 704
Patent
active
059853182
ABSTRACT:
Liposomes which have present on their surface a polypeptide capable of binding to a mucosal cell surface of a human or animal and which are substantially free of active neuraminidase are useful as vaccines.
REFERENCES:
patent: 4235877 (1980-11-01), Fullerton
Hackett C, Taylor P, Askonas B; Stimulation of cytotoxic T cells by liposomes containing influenza virus or its components Immunology 29: 255-262, 1983.
Yewdell J, Bennink J, Hosaka Y; Cells process exogenous proteins for recognition by cytotoxic T lymphocytes Science 239: 637-640, 1988.
Martindale: The Extra Pharmacopoeia, Twenty-nineth Edition, James E.F. Reynolds, Editor, London, The Pharmaceutical Press, pp. 1165-1166 (1989).
Schulman et al, Protective Effects of Specific Immunity to Viral Neuraminidase on Influenza Virus Infection of Mice, Journal of Virology 2(8):77-786 (1968).
Couch et al, "Induction of Partial Immunity to Influenza by a Neuraminidase-specific Vaccine", The Journal of Infectious Diseases 129(4):411-420 (1974).
Beutner et al, "Evaluation of a Neuraminidase-Specific Influenza A Virus Vaccine in Children: Antibody Responses and Effects on Two Successive Outbreaks of Natural Infection", The Journal of Infectious Diseases 140(6):844-850 (1979).
Burroughs Wellcome Co.
Park Hankyel T.
Stucker Jeffrey
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