Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1994-11-03
1996-02-20
Lilling, Herbert J.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
4241301, 4241641, 4241761, 4241841, 42419711, 435 713, 435243, 4352521, 435822, A61K 3900, A61K 3902
Patent
active
054926947
ABSTRACT:
A method is provided for the enhanced elaboration of leukotoxin from F. necrophorum, and subsequent production of an inactivated leukotoxoid ruminant animal vaccine against F. necrophorum infection and consequent liver abscesses and/or foot rot in such animals. The method involves forming a culture of F. necrophorum bacteria in growth media, allowing the bacteria to grow therein and to simultaneously elaborate leukotoxin in a supernate; the culturing is preferably carried out at a temperature of from about 35.degree.-41.degree. C., a pH of from about 6.5-8, and for a period of from about 4-9 hours. At the end of the culturing, bacterial growth and leukotoxin elaboration are terminated, preferably by separating the leukotoxin supernate, whereupon the vaccine is produced by inactivation of at least the supernate.
REFERENCES:
patent: 4152415 (1979-05-01), Harris et al.
patent: 4919929 (1990-04-01), Beck
Emery et al "Vet. Microbiol." 12, 255-268 (1986) Generation of Immunity Against Fusobacterium Necrophorum in Mice Inocculated with Extracts Containing Leucocidin.
Emery et al "Australian Vet J." (61): 382-385 (1984) Biochemical and Functional Properties of a Leucocidin Produced by Several Strains of Fusobacterium Necrophorum.
Chengappa Muckatira M.
Nagaraja Tiruvoor G.
Kansas State University Research Foundation
Lilling Herbert J.
LandOfFree
Fusobacterium leukotoxoid vaccine does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Fusobacterium leukotoxoid vaccine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fusobacterium leukotoxoid vaccine will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1354749