Fusion proteins with cleavable spacers and uses thereof

Details Fusion proteins with cleavable spacers and uses thereof Fusion proteins with cleavable spacers and uses thereof

2011-06-07

2011-06-07

Tsang, Cecilia (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

C530S326000

Reexamination Certificate

active

07956158

ABSTRACT:
A polypeptide comprising a first protein domain, a second protein domain, and a dithiocyclopeptide spacer containing at least one protease cleavage site, wherein the dithiocyclopeptide is exogenous relative to the first or second protein domain, and wherein the first and second protein domains are operably linked by the dithiocyclopeptide. Also disclosed are methods of producing the polypeptide and delivering the protein domains into a cell.

REFERENCES:
patent: 2005034877 (2005-04-01), None
patent: WO 2005/034877 (2005-04-01), None
International Search Report for corresponding PCT application PCT/US08/58789 lists the reference above.

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