Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant virus encoding one or more heterologous proteins...
Reexamination Certificate
2006-07-18
2009-08-04
Parkin, Jeffrey S. (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant virus encoding one or more heterologous proteins...
C424S208100, C424S232100
Reexamination Certificate
active
07569228
ABSTRACT:
Nucleic acids are disclosed encoding fusion proteins comprising the amino acid sequence of at least four non-attenuated HIV proteins selected from the group consisting of Vif, Vpr, Vpu, Vpx, Rev, Tat, and Nef, wherein the fusion protein does not contain a specific cleavage sequence for a cellular protease. Also disclosed are vectors comprising the nucleic acids and methods of preparing the fusion protein by transfecting a host cell with the nucleic acids or with the vectors containing the nucleic acids, expressing the fusion proteins, and recovering the fusion proteins.
REFERENCES:
patent: 2002/0015707 (2002-02-01), Rutter et al.
patent: 2005/0260156 (2005-11-01), Suter et al.
patent: WO 99/16884 (1999-04-01), None
patent: WO 99/27958 (1999-06-01), None
patent: WO 99/43841 (1999-09-01), None
patent: WO 01/54719 (2001-08-01), None
patent: WO 01/92470 (2001-12-01), None
patent: WO 02/04493 (2002-01-01), None
patent: WO 02/06303 (2002-01-01), None
patent: WO 02/36806 (2002-05-01), None
Kusumi et al. Human immunodeficiency virus type 1 envelope gene structure and diversity in vivo and after cocultivation in vitro. Journal of Virology, Feb. 1992, vol. 66, No. 2, p. 875-885.
Meyerhans et al. Temporal fluctuations in HIV quasispecies in vivo are not reflected by sequential HIV isolations. Cell 1989, vol. 58, p. 901-910.
Rossi et al. Ribozymes as anti-HIV-1 therapeutic agents: principles, applications, and problems. AIDS research and human retroviruses Feb. 1992, vol. 8, No. 2, p. 183-189. Abstract only.
Derosiers. Prospects for an AIDS vaccine: Nature Medicine Mar. 2004, vol. 10, No. 3, p. 221-223.
Leslie et al. HIV evolution: CTL escape mutation and reversion after transmission. Nature Medicine Mar. 2004 vol. 10, No. 3, p. 282-289.
Altman et al. HIV escape: there and back again. Nature Medicine Mar. 2004 vol. 10, No. 3, p. 229-230.
Friedrich et al. Reversion of CTL escape—variant immunodeficiency viruses in vivo. Nature Medicine Mar. 2004 vol. 10, No. 3, p. 275-281.
“Immunogenicity of a Novel and Vaccine Cassette expressing multiple human immunodeficiency virus (HIV-1) accessory genes”, Velpandi Ayyavoo et al.;AIDS14(1):1-9 (2000).
“DNA vaccination in mice using HIV-1 nef, rev and tat genes in self-replicating pBN-vector.”, Tahtinen et al.,:Vaccine19:2039-2047 (2001).
“Control of a Mucosal Challenge and Prevention of AIDS by a multiprotein DNA/MVA vaccine”, Amara et al.,Science292:69-74 (2001).
“Activation of transcription by HIV-1 TAT protein tethered to nascent RNA through another protein”, Southgate,Nature345:640-642 (1990).
“Construction of attenuated HIV-1 accessory gene immunization cassettes”, Ayyavoo et al.,Vaccine16:1872-1879 (1998).
“Recognition of Prominent Viral Epitopes Induced by Immunization with Human Immunodeficiency Virus Type 1 Regulatory Genes”, Hinkula et al.,J. Virology71:5528-5539 (1997).
“Membrane-Fusing Capacity of the Human Immunodeficiency Virus Envelope Proteins Determines the Efficiency of CD4+ T-Cell Depletion in Macaques Infected by a Simian-Human Immunodeficiency Virus” Etemad-Moghadam et al., J. Virology 75:5645-5655 (2001).
Felder Eva
Howley Paul
Leyer Sonja
Bavarian Nordic A/S
Humphrey Louise
Law Office of Salvatore Arrigo
Parkin Jeffrey S.
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