Fusion proteins of mycobacterium tuberculosis antigens and...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C424S009200, C424S130100, C424S164100, C424S168100, C424S190100, C424S248100, C435S069100, C435S069300, C514S04400A, C530S350000, C536S023100

Reexamination Certificate

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07064195

ABSTRACT:
The present invention relates to fusion proteins ofMycobacterium tuberculosisantigens. In particular, it relates to two fusion proteins, each of which contains three individualM. tuberculosisantigens, and a fusion protein of twoM. tuberculosisantigens, their coding sequences, and methods for their use in the treatment and prevention of tuberculosis.

REFERENCES:
patent: 5330754 (1994-07-01), Kapoor et al.
patent: WO 95/01440 (1995-01-01), None
patent: WO 95/14713 (1995-06-01), None
patent: WO 97/09428 (1997-03-01), None
patent: WO 97/09429 (1997-03-01), None
Philipp et al., An integrated map of the genome of the tubercle bacillusMycobacterium tuberculosisH37Rv, and comparison withMycobacterium leprae, Proc. Natl. Acad. Sci,93:3132-3137 (1996).
Lee et al., Characterization of the Major Membrane Protein of VirulentMycobacterim tuberculosis, Infection and Immunity, p. 2066-2074 (May 1992).
Pal et al., “Immunization with Extracellular Proteins ofMycobacterium tuberculosisInduces Cell-Mediated Immune Responses and Substantial Protective Immunity in a Guinea Pig Model of Pulmonary Tuberculosis”;Infection and Immunityvol. 60, No. 11, pp. 4781-4792 (Nov. 1992).

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