Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Testing efficacy or toxicity of a compound or composition
Reexamination Certificate
2005-12-20
2005-12-20
Swartz, Rodney P (Department: 1645)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Testing efficacy or toxicity of a compound or composition
C424S009100, C424S130100, C424S164100, C424S168100, C424S190100, C424S248100, C435S069100, C435S069300, C530S300000, C530S350000, C536S023100, C536S023700
Reexamination Certificate
active
06977069
ABSTRACT:
The present invention relates to fusion proteins containing at least twoMycobacterium tuberculosisantigens. In particular, it relates to bi-fusion proteins which contain two individualM. tuberculosisantigens, tri-fusion proteins which contain threeM. tuberculosisantigens, tetra-fusion proteins which contain fourM. tuberculosisantigens, and penta-fusion proteins which contain fiveM. tuberculosisantigens, and methods for their use in the diagnosis, treatment and prevention of tuberculosis infection.
REFERENCES:
patent: 5330754 (1994-07-01), Kapoor et al.
patent: WO 95/01440 (1995-01-01), None
patent: WO 95/14713 (1995-06-01), None
patent: WO 97/09428 (1997-03-01), None
patent: WO 97/09429 (1997-03-01), None
Pal et al., “Immunization with Extracellular Proteins ofMycobacterium turberculosisInduces Cell-Mediated Immune Responses and Substantial Protective Immunity in a Guinea Pig Model of Pulmonary Tuberculosis”;Infection and Immunityvol. 60, No. 11, pp. 4781-4792 (Nov. 1992).
Philipp et al., An integrated map of the genome of the tubercle bacillusMycobacterium tuberculosisH37Rv, and comparison withMycobacterium Ieprae, Proc. Natl. Acad. Sci, 93:3132-3137 (1996).
Lee et al., Characteriztion of the Major Membrane Protein of VirulentMycobacterim tuberculosis, Infection and Immunity, p. 2066-2074 (May 1992).
Alderson Mark
Campos-Neto Antonio
Dillon Davin C.
Reed Steven G.
Skeiky Yasir A.
Corixa Corporation
Swartz Rodney P
Townsend and Townsend / and Crew LLP
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