Fusion proteins of mycobacterium tuberculosis

Details Fusion proteins of mycobacterium tuberculosis Fusion proteins of mycobacterium tuberculosis

2007-08-28

2007-08-28

Swartz, Rodney P (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fusion protein or fusion polypeptide

C424S130100, C424S164100, C424S168100, C424S190100, C424S248100, C435S069100, C435S069300, C530S300000, C530S350000, C536S023100, C536S023700

Reexamination Certificate

active

11396117

ABSTRACT:
The present invention relates to compositions and fusion proteins containing at least twoMycobacteriumsp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.

REFERENCES:
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patent: 6544522 (2003-04-01), Skeiky et al.
patent: 6627198 (2003-09-01), Reed et al.
patent: WO99/51748 (1999-10-01), None
Cole, et al. “Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence”; Nature, vol. 393, pp. 537-544 (Jun. 1998).
Content, et al., “The Genes Coding for the Antigen 85 Complexes of Mycobacterium tuberculosis and Mycobacterium bovis BCG Are Members of a Gene Family: Cloning, Sequence Determination, and Genomic Organization of the Gene Coding for Antigen 85-C of M. tuberculosis”; Infection and Immunity, vol. 59, No. 9, pp. 3205-3212 (Sep. 1991).
Verbon, et al., “The 14,000-Molecular-Weight Antigen of Mycobacterium tuberculosis Is Related to the Alpha-Crystallin Family of Low-Molecular-Weight Heat Shock Proteins”; Journal of Bacteriology, vol. 174, No. 4, pp. 1352-1359 (Feb. 1992).

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