Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
2007-03-06
2007-03-06
Swartz, Rodney P (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
C424S009200, C424S130100, C424S164100, C424S168100, C424S248100, C530S300000, C530S350000, C536S023100, C536S023700
Reexamination Certificate
active
09597796
ABSTRACT:
The present invention relates to compositions and fusion proteins containing at least twoMycobacteriumsp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected withtuberculosis, and methods for their use in the diagnosis, treatment, and prevention oftuberculosisinfection.
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patent: WO 99/51748 (1999-10-01), None
Cole, et al. “Deciphering the biology ofMycobacterium tuberculosisfrom the complete genome sequence”;Nature,vol. 393, pp. 537-544 (Jun. 1998).
Content, et al., “The Genes Coding for the Antigen 85 Complexes ofMycobacterium tuberculosisandMycobacterium bovisBCG Are Members of a Gene Family: Cloning, Sequence Determination, and Genomic Organization of the Gene Coding for Antigen 85-C ofM. tuberculosis”; Infection and Immunity,vol. 59, No. 9, pp. 3205-3212 (Sep. 1991).
Verbon, et al., “The 14,000-Molecular-Weight Antigen ofMycobacterium tuberculosisIs Related to the Alpha-Crystallin Family of Low-Molecular-Weight Heat Shock Proteins”;Journal of Bacteriology,vol. 174, No. 4, pp. 1352-1359 (Feb. 1992).
Alderson Mark
Reed Steven
Skeiky Yasir
Corixa Corporation
Swartz Rodney P
Townsend and Townsend / and Crew LLP
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