Fusion proteins of mycobacterium tuberculosis

Details Fusion proteins of mycobacterium tuberculosis Fusion proteins of mycobacterium tuberculosis

2006-08-01

2006-08-01

Swartz, Rodney P (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

C424S009100, C424S009200, C424S184100, C424S185100, C424S190100, C424S192100, C424S234100, C424S278100, C530S300000, C530S350000

Reexamination Certificate

active

07083796

ABSTRACT:
The present invention relates to compositions and fusion proteins containing at least twoMycobacteriumsp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.

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Content, et al., “The Genes Coding for the Antigen 85 Complexes ofMycobacterium tuberculosisandMycobacterium bovisBCG Are Members of a Gene Family: Cloning, Sequence Determination, and Genomic Organization of the Gene Coding for Antigen 85-C ofM. tuberculosis”; Infection and Immunity, vol. 59, No. 9, pp. 3205-3212 (Sep. 1991).
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Wang, et al., “A novel method for increasing the expression level of recombinant proteins,”Protein Expression and Purification, Jul. 2003, vol. 30, No. 1, pp. 124-133.

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