Fusion proteins of Mycobacterium tuberculosis

Details Fusion proteins of Mycobacterium tuberculosis Fusion proteins of Mycobacterium tuberculosis

2006-04-11

2006-04-11

Swartz, Rodney P (Department: 1645)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C424S009100, C424S009200, C424S184100, C424S192100, C424S248100, C536S023100, C536S023700

Reexamination Certificate

active

07026465

ABSTRACT:
The present invention relates to compositions and fusion proteins containing at least twoMycobacteriumsp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.

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patent: WO 99/51748 (1999-10-01), None
patent: WO 99/51748 (1999-10-01), None
Cole, et al. “Deciphering the biology ofMycobacterium tuberculosisfrom the complete genome sequence”; Nature, vol. 393, pp. 537-544 (Jun. 1998).
Content, et al., “The Genes Coding for the Antigen 85 Complexes ofMycobacterium tuberculosisandMycobacterium bovisBCG Are Members of a Gene Family: Cloning, Sequence Determination, and Genomic Organization of the Gene Coding for Antigen 85-C ofM. tuberculosis”; Infection and Immunity, vol. 59, No. 9, pp. 3205-3212 (Sep. 1991).
Verbon, et al., “The 14,000-Molecular-Weight Antigen ofMycobacterium tuberculosisIs Related to the Alpha-Crystallin Family of Low-Molecular-Weight Heat Shock Proteins”; Journal of Bacteriology, vol. 174, No. 4, pp. 1352-1359 (Feb. 1992).

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