Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Reexamination Certificate
2004-02-18
2008-11-25
Carlson, Karen Cochrane (Department: 1656)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
Reexamination Certificate
active
07456257
ABSTRACT:
The invention concerns human interferon alpha and in particular modified forms of interferon alpha 2 with improved properties. The improved proteins contain amino acid substitutions at specific positions that confer increased relative activity in biological assays. The invention provides also modified interferon alpha with improved biological activity concomitant with reduced immunogenic potential in the protein. The improved proteins are intended for therapeutic use in the treatment of diseases in humans.
REFERENCES:
patent: 2002/0081664 (2002-06-01), Lo et al.
patent: WO 02/085941 (2002-10-01), None
Baker Matthew
Carr Francis Joseph
Hanlon Marian
Jones Tim
Carlson Karen Cochrane
Merck Patent GmbH
Olson & Cepuritis, Ltd.
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