Fusion proteins of interferon alpha muteins with improved...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.

Reexamination Certificate

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Reexamination Certificate

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07456257

ABSTRACT:
The invention concerns human interferon alpha and in particular modified forms of interferon alpha 2 with improved properties. The improved proteins contain amino acid substitutions at specific positions that confer increased relative activity in biological assays. The invention provides also modified interferon alpha with improved biological activity concomitant with reduced immunogenic potential in the protein. The improved proteins are intended for therapeutic use in the treatment of diseases in humans.

REFERENCES:
patent: 2002/0081664 (2002-06-01), Lo et al.
patent: WO 02/085941 (2002-10-01), None

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