Fusion proteins of immunopotentiating activity

Details Fusion proteins of immunopotentiating activity Fusion proteins of immunopotentiating activity

1996-02-05

1999-06-29

Caputa, Anthony C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

4353201, 43525233, 4352402, 4352523, 4242781, 514885, 530300, 530350, 536 231, C07H 2104

Patent

active

059170263

ABSTRACT:
A DNA-sequence comprising a first sequence coding for a native or mutant subunit of a bacterial toxin that confers enzymatic ADP-ribosylating activity, and a second sequence coding for a peptide such that the resulting fusion protein is in possession of water solubility and capability of targeting the fusion protein to a specific cell receptor different from receptors binding to the native toxin, thereby mediating intracellular uptake of at least said subunit;
fusion proteins coded for by such DNA-sequence;
compositions for use in improving immune functions; and
recombinant expression vectors and transformed bacterial cells containing such DNA-sequence.

REFERENCES:
patent: 5143844 (1992-09-01), Abrahmsen et al.
Roit et al "Immunology" 3.sup.rd Edition, Mosby Press, St. Louis pp. 1.1-1.12 and 5.10 (1993).
Osband et al Immunology Today vol. 11, No. 6 (1990) pp. 193-195.
Herbert et al (eds) The Dictionary of Immunology, Academic Press, Harcourt Brace & Company, London (1995) pp. 62-63.
Lycke et al Immunology (1986) 59 pp. 301-308.

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