Fusion proteins for protein delivery

Details Fusion proteins for protein delivery Fusion proteins for protein delivery

1997-10-24

2000-06-06

Park, Hankyel

Chemistry: natural resins or derivatives; peptides or proteins;

Involving immunoglobulin or antibody fragment,

514 12, 536 231, 530867, 530402, 5303911, 5303917, C07K 100, C07K 1600, A61K 3800, C07H 2102

Patent

active

060720417

ABSTRACT:
A protein conjugate consisting of antibody directed at the pIgR and A.sub.1 AT can be transported specifically from the basolateral surface of epithelial cells to the apical surface. This approach provides us with the ability to deliver a therapeutic protein directly to the apical surface of the epithelium, by targeting the pIgR with an appropriate ligand. Thus, the highest concentration of the antiprotease will be at the apical surface, where it can do the greatest good in accelerating the inflammatory response.

REFERENCES:
patent: 5108921 (1992-04-01), Low et al.
Elizabeth Eckman et al., Pediatric Pulmonology 14 (Suppl.): A229 "Targeting the Polymeric Immunoglobulin Receptor as a Means of Directing Therapeutic Proteins to the Airway", 1997.
Elizabeth Eckman et al., Pediatridic Pulmonology 13 (Suppl.) A242 "Structure and Function of Anti-Human Secretory Component FV/Human Alpha 1-Antitrypsin Fusion Proteins", 1997.
Ernst Wagner et al. "Transferrin-polycation-DNA complexes: The effect of polycations on the structure of the complex and DNA delivery to cells" Proc. Natl. Acad. Sci. USA vol. 88, pp. 4255-4259, May 1991.

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