Fusion proteins for prodrug activation

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

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C435S069700, C435S091200, C435S348000, C435S352000, C435S358000, C435S365000, C435S367000, C435S414000, C800S006000, C800S008000

Reexamination Certificate

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11135155

ABSTRACT:
The invention relates to compounds which contain an antigen binding region which is bound to at least one enzyme which is able to metabolize a compound (prodrug) which has little or no cytotoxicity to a cytotoxic compound (drug), where the antigen binding region is composed of a single polypeptide chain. It is advantageous for covalently bonded carbohydrates to be present on the polypeptide chain.

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