Fusion proteins comprising MGF and IL-3

Details Fusion proteins comprising MGF and IL-3 Fusion proteins comprising MGF and IL-3

1991-11-22

1994-12-27

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

435 697, 435 6952, 530350, 530351, 530402, 424 851, A61K 4505, C12P 2106, C07K 1300

Patent

active

053763670

ABSTRACT:
A fusion protein which comprises MGF and IL-3. Such fusion proteins have enhanced biological activity.

REFERENCES:
Tsuji et al. J. Cell Physiol. Sep. 1991, 148(3):362-9 [abstract only].
Broxmeyer et al., J. Exp. Med. Aug. 1, 1991, 174(2)447-458 [abstract only].
Martin et al., "Primary Structure and Functional Expression of Rat and Human Stem Cell Factor DNAs", Cell 63:203 (Oct. 1990).
Curtis et al., "Enhanced hematopoietic activity of a human granulocyte/macrophage colony-stimulating factor--interleukin 3 fusion protein", Proc. Natl. Acad. Sci. USA, 88:5809 (Jul. 1991).
Williams et al., "Identification of a Ligand for the c--kit Proto-Oncogene", Cell 63:167 (Oct. 1990).
Anderson et al., "Molecular Cloning of Mast Cell Growth Factor, a Hematopoietin That is Active in Both Membrane Bound and Soluble Forms", Cell 63:235 (Oct. 1990).
Zsebo et al., "Identification, Purification, and Biological Characterization of Hematopoietic Stem Cell Factor from Buffalo Rat Liver-Conditioned Medium", Cell 63:195 (Oct. 1990).

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