Fusion proteins comprising GM-CSF and IL-3

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.

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Details

530402, 530403, 530404, 530405, 530808, 435 695, 435 6952, 435 697, C07K 1300, A61K 3702, C12P 2102

Patent

active

050736272

ABSTRACT:
A fusion protein is disclosed which comprises GM-CSF and IL-3. Such fusion proteins more biologically active than GM-CSF or IL-3 alone or GM-CSF and IL-3 combined.

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Donohue et al., "Human IL-3 and GM-CSF Act Synergistically in Stimulating Hematopoiesis in Primates," Science 241:1820 (1988).
Broxmeyer et al., "Synergistic myelopoietic actions in vivo after administration to Mico of combinations of purified natural murine colony-stimulating factor 1, recombinant murine interleukin 3, and recombinant murine granulocyte/macrophage colony-stimulating factor," Proc. Natl. Acad. Sci. 84:3871 (1987).
Krumwich et al., "Human Recombinant Derived IL-3 and GM-CSF of Normal Cynomolgus Monkeys," Behring Inst. Mitt. 83:250 (1988).
Park et al., "Heterogeneity in Human Interleukin-3 Receptors," J. Biol. Chem. 264:5420 (1989).
Yang et al., "The Human Genes for GM-CSF and IL-3 are Closely Linked in Tandem on Chromosome 5," Blood 71:958 (1988).
Barlow et al., "Close genetic and physical linkage between the murine Haemopoietic growth factor genes GM-GSF and Multi-CSF (IL3)," EMBO J. 6:617 (1987).
Kelso et al., "Independent Regulation of Granulocyte-Macrophage Colony-Stimulating Factor and Multi-Lineage Colony-Stimulating Factor Production in T Lymphocyte Clones," J. Immunol. 136:1718 (1986).

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