Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1990-08-14
1991-12-17
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530402, 530403, 530404, 530405, 530808, 435 695, 435 6952, 435 697, C07K 1300, A61K 3702, C12P 2102
Patent
active
050736272
ABSTRACT:
A fusion protein is disclosed which comprises GM-CSF and IL-3. Such fusion proteins more biologically active than GM-CSF or IL-3 alone or GM-CSF and IL-3 combined.
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Krumwich et al., "Human Recombinant Derived IL-3 and GM-CSF of Normal Cynomolgus Monkeys," Behring Inst. Mitt. 83:250 (1988).
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Yang et al., "The Human Genes for GM-CSF and IL-3 are Closely Linked in Tandem on Chromosome 5," Blood 71:958 (1988).
Barlow et al., "Close genetic and physical linkage between the murine Haemopoietic growth factor genes GM-GSF and Multi-CSF (IL3)," EMBO J. 6:617 (1987).
Kelso et al., "Independent Regulation of Granulocyte-Macrophage Colony-Stimulating Factor and Multi-Lineage Colony-Stimulating Factor Production in T Lymphocyte Clones," J. Immunol. 136:1718 (1986).
Cosman David J.
Curtis Benson M.
Park Linda S.
Draper Garnette D.
Immunex Corporation
Wight Christopher L.
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