Fusion proteins comprising GM-CSF and antigens and their express

Details Fusion proteins comprising GM-CSF and antigens and their express Fusion proteins comprising GM-CSF and antigens and their express

1996-05-02

1997-04-01

Ulm, John

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 697, 4352523, 4353201, 536 234, C12N 119, C12N 1527, C12N 1562

Patent

active

056164777

ABSTRACT:
Novel fusion proteins that enhance the immune response of an antigen are efficiently expressed and secreted by yeast host cells. The fusion proteins are recombinantly made by fusing the 3'-end of mature GM-CSF DNA sequence to the 5'-end of an antigen DNA sequence with or without a linker sequence. Methods of expression in yeast cells are provided.

REFERENCES:
B. M. Curtis et al., P.N.A.S. 88:5809-5813, Jul. 1991.
V. Price, Gene 55:287-293, 1987.
Tao and Levy, Nature, 362:755-758 (1993).
Dranoff et al., Proc. Natl. Acad. Sci. USA 90:3539 (1993).

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