Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1994-04-08
1997-06-03
Walsh, Stephen G.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530350, 435 691, 435 695, 435 6952, 435 697, 4351723, C07K 1900, C07K 14535, C07K 1455, C07K 1454
Patent
active
056355998
ABSTRACT:
The present invention provides for circularly permuted ligands which possess specificity and binding affinity comparable to or greater than the specificity and binding affinity of the original (unpermuted) ligand. The invention further provides for novel fusion proteins comprising a circularly permuted ligand fused to one or more proteins of interest.
REFERENCES:
The Journal of Biological Chemistry, vol. 268, No. 19, 5 Jul. 1993 pp. 14065-14070, Waldemar Debinski et al. see p. 14068, first paragraph of the Discussion.
Science, vol. 245, 29 Sep. 1989 pp. 1493-1496, Cynthia E. Dunbar et al., `Carboxyl-terminal-modified interleukin-3 is retained intracellularly and stimulates autocrine growth` see the whole document.
Cancer Research, vol. 55, No. 15, 1 Aug. 1995 pp. 3357-3363, Robert J. Kreitman et al., `Increased antitumor activity of a circularly permuted interleukin 4-toxin in mice with interleukin 4 receptor-bearing human carcinoma`.
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Pan, et al. Circularly permuted DNA, RNA and proteins--a review. Gene, 125:11-114 (1993).
Kreitman Robert J.
Pastan Ira H.
Puri Raj K.
Kemmerer Elizabeth C.
The United States of America as represented by the Department of
Walsh Stephen G.
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