Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fusion protein or fusion polypeptide
Reexamination Certificate
2005-06-28
2005-06-28
Foley, Shanon (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fusion protein or fusion polypeptide
C424S185100, C424S186100, C424S198100, C424S204100, C424S229100, C424S546000, C530S350000, C530S398000, C530S399000
Reexamination Certificate
active
06911206
ABSTRACT:
The subject invention provides a fusion protein for producing a dual immune response in a vertebrate, which fusion protein comprises: (a) a first proteinaceous portion analogous to all or part of a peptide endogenously synthesized within the vertebrate, the activity of which peptide is to be inhibited within the vertebrate, and which proteinaceous portion by itself is incapable of eliciting an effective immunoinhibitory response in said vertebrate; connected to (b) a second proteinaceous portion analogous to all or part of an immunogen from a pathogen, which pathogen is capable of pathogenically infecting the vertebrate; the portion (b) causing the vertebrate's immune system to recognize the portion (a) and produce a response that: (i) inhibits the activity of the peptide endogenously synthesized within the vertebrate; and (ii) protects the vertebrate from infection by the pathogen, when the vertebrate is vaccinated with an effective amount of the fusion protein. The subject invention also provides fusion proteins which comprise a proteinaceous portion (b) that is a carrier that is analogous to all or part of a BHV-1 antigen, which fusion proteins induce in a vertebrate vaccinated with an effective amount of such fusion protein an immune response that inhibits the activity of a peptide as recited in (a), above.
REFERENCES:
patent: 3137631 (1964-06-01), Soloway
patent: 3959457 (1976-05-01), Speaker et al.
patent: 4016100 (1977-04-01), Suzuki et al.
patent: 4205060 (1980-05-01), Monsimer et al.
patent: 4452747 (1984-06-01), Gersonde et al.
patent: 4606940 (1986-08-01), Frank et al.
patent: 4722840 (1988-02-01), Valenzuela et al.
patent: 4744933 (1988-05-01), Rha et al.
patent: 4921706 (1990-05-01), Roberts et al.
patent: 4927637 (1990-05-01), Morano et al.
patent: 4944948 (1990-07-01), Uster et al.
patent: 4975420 (1990-12-01), Silversides et al.
patent: 5008050 (1991-04-01), Cullis et al.
patent: 5009956 (1991-04-01), Baumann
patent: 5132117 (1992-07-01), Speaker et al.
patent: 5151267 (1992-09-01), Babiuk et al.
patent: 5403586 (1995-04-01), Russell-Jones et al.
patent: 5422110 (1995-06-01), Potter et al.
patent: 5441736 (1995-08-01), Gerlach et al.
patent: 5545523 (1996-08-01), Batt et al.
patent: 5585264 (1996-12-01), Babiuk et al.
patent: 5599663 (1997-02-01), Vaughan
patent: 5612360 (1997-03-01), Boyd et al.
patent: 5629292 (1997-05-01), Rodgers et al.
patent: 5635359 (1997-06-01), Brunner et al.
patent: 5665568 (1997-09-01), Mason et al.
patent: 5684145 (1997-11-01), Van Der Zee et al.
patent: 5786179 (1998-07-01), Kousoulas et al.
patent: 5795967 (1998-08-01), Aggarwal et al.
patent: 6086902 (2000-07-01), Zamb et al.
patent: 0131363 (1985-01-01), None
patent: 0175261 (1986-03-01), None
patent: 0888777 (1999-01-01), None
patent: 2140810 (1984-12-01), None
patent: 1989171489 (1989-07-01), None
patent: 1994073095 (1994-03-01), None
patent: WO 84/04756 (1984-12-01), None
patent: WO 86/06635 (1986-11-01), None
patent: WO 90/02187 (1990-03-01), None
patent: WO 91/15571 (1991-10-01), None
patent: WO 92/03558 (1992-03-01), None
patent: WO 93/14209 (1993-07-01), None
patent: WO 95/28227 (1995-10-01), None
patent: WO 96/24775 (1996-08-01), None
patent: WO 98/32866 (1998-07-01), None
patent: WO 99/02180 (1999-01-01), None
Roeske et al. (sequence alignment of SEQ ID No.: 13 with Geneseq accession No.: AAP50222, first entry: Jan. 20, 1992 by Roeske et al. in EP13573-A).
Russelljon et al. (sequence alignment of SEQ ID No.: 15 with Geneseq accession No.: AAR11187, first entry: May 22, 1991 in WO 91/02799-A).
Babiuk et al. (sequence alignment of SEQ ID No.: 19 with Geneseq accession No.: AAR37895, first entry: Dec. 1, 1993 in WO 93/11792-A1).
Zhu et al. Vaccine. 1996; 14 (1): 61-69.
Zhu et al. Vaccine. Jan. 21, 1999; 17: 269-282.
Van Druden Littel-Van den Hurk et al. Virology. 1985; 144: 216-227.
Mittal et al. 1996. Induction of systemic and mucosal immune responses in cotton rats immunized with human adenovirus type 5 recombinants expressing the full and truncated forms of bovine herpesvirus type 1 glycoprotein gD. Virology. vol. 222,pp. 299-309.
Bakker, D. et al., Identification of Minor Fimbrial Subunits Involved in Biosynthesis of K88 Fimbriae. Journal of Bacteriology vol. 174, No. 20, pp. 6350-6358, 1992.
Engstrom, A. The Arrangment of the Protein Molecules in Nuclear-Polyhedrosis Inclusions. Biochem. Exp. Biol. 11:7-13, 1974.
Gerlach, G.F. et al. Characterization of Two Genes Encoding Distinct Transferrin-Binding Proteins in Different Actinobacillus. Infection and Immunity vol. 60, No. 8, pp. 3253-3261, 1992.
Ferro, V.A. and Stimson, W.H. Investigation into Suitable Carrier Molecules for Use in an Anti-Gonadotrophin Releasing Hormone Vaccine. Vaccine, vol. 16, No. 11/12, pp. 1095-1102, 1998.
Hsiung, N. et al. Efficient Production of Hepatitis B. Surface Antigen Using a Bovine Papilloma Virus-Metallothionein Vector. Journal of Molecular and Applied Genetics vol. 2, pp. 497-506, 1984.
Simons, B.L. et al. The Periltimate Tyrosine residue of the K99 Fibrillar Subunit is Essential for Stability of the Protein and Its Interaction with the Periplasmic Carrier Protein, FEMS Microbiol. Letters vol. 67, pp. 107-112, 1990.
Ausubel et al., 1989, Current Protocols In Molecular Biology, Greene Publishing Associates & Wiley Interscience, NY.
Bernatowics, M. and Matsueda, G., Analytical Biochemistry 155:95-102, 1986.
Chasin, M. and Langer, R. (eds), 1990, “Biodegradable Polymers as Drug Delivery Systems” in Drugs and the Pharmaceutical Sciences, vol. 45, M. Dekker, NY.
A. Domb et al., Polymers for Advanced Technologies, 3:279-292, 1992.
Erlich (ed), PCR Technology, Oxford University Press, New York, 1992.
Harlow, E., Lane, D., Antibodies, A Laboratory Manual, Cold Springs Harbor Laboratory, 1988.
Hopp and Woods, Proc. Natl. Acad. Sci. U.S.A. 78:3824, 1981.
Köhler, G., Milstein, C., Continuous cultures of fused cells secreting antibody of predefined specificity, Nature, vol. 256:495-497, Aug. 7, 1975.
Ladd, A: et al., Biol. Reprod. 51:1076-1083, 1994.
Ladd, A. et al., Biol. Reprod. 15:85-101, 1989.
Marshak, DR., Kadonaga, JT., Burgess, RR., Knuth, MW., Brennan, WA. Jr., Lin, S., “Strategies for Protein Purification and Characterization. A laboratory course manual”, CSHL Press, 1996.
Sambrook et al., Molecular Cloning: A Laboratory Manual, 2nded., Cold Springs Harbor Laboratory Press, Cold Springs Harbor, NY, 1989.
van Drunen Little-van der Hurk, S. et al., Vaccine 11:25-35, 1993.
Babiuk, L.A., et al., Virology 159:57-66, 1987.
Batista, F.D. et al., Nucleic Acids Res. 23(23):4805-4811, 1995.
Britton, P. et al., Virus Res. 21(3):181-198, 1991.
Cole et al., Monoclonal Antibodies and Cancer Therapy, Alan R. Liss, Inc., pp. 77-96, 1985.
Cote et al., Proc. Natl. Acad. Sci. U.S.A. 80:2026-2030, 1983.
Dimaline, R. et al., FEBS Lett. 205(2):318-322, 1986.
Dunn and Pennignton, Methods in Molecular Biology, vol. 26, Chap. 10, Humana Press Inc., 1994.
Edge. Nature, 292:756, 1981.
Eng, J. et al., Regul, Pept., 30(1):15-19, 1990.
Fairweather, N.F. et al., J. Bacteriol. 165(1):21-27, 1986.
Fitzpatrick, D.R. et al., Virology 173:456-457, 1989.
Fletterick and Zoller (eds), Current Communications in Molecular Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 1986.
Frey, J. et al., Infect. Immun. 59(9), 3026-3032, 1991.
Fritzemier, J. et al., Arch. Virol. 142(7):1335-1350, 1997.
Furze, J.M. et al., Virology 231(1):48-58, 1997.
Goding, J.W., Monoclonal Antibodies: Principles and Practice, Academic Press, London, 1986.
Gompels, U.A. et al., DNA Seq. 3(1):25-39, 1992.
Gubler, U. et al. Proc. Natl. Acad. Sci. U.S.A. 80(14):4311-4314, 1983.
Hovanec, D.L. and Air, G.M., Virology 139(2):384-392, 1984.
Innis et al. (eds.), PCR Strategies, Academic Press, Inc., San Diego, 1995.
Inoue, T. et al., FEMS Microbiol. Lett. 108(2):157-161, 1993.
Jay et al., J. Biol. Chem. 259:6311, 1984.
Jerse, A.E. et al., Proc. Natl. Acad. Sci. U.S.A. 87(20):7839-7843, 1990.
Kambadur, R. et al., Genome Res. 7(9):910-916, 1997.
Kariya, Y. et al., Gene 40(1-3):345-52, 1986.
Kim, S.J. et al., DNA
Campos Manuel
Durtschi Becky A.
Martinod Serge
Yule Terecita D.
Foley Shanon
Kohn Kenneth I.
Kohn & Associates PLLC
Pfizer Inc.
Pfizer Products Inc.
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