Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2010-03-10
2011-12-13
Landsman, Robert (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C435S069100, C435S252300, C435S320100, C435S471000, C530S300000, C536S023100, C536S023500
Reexamination Certificate
active
08076456
ABSTRACT:
The present invention discloses a canine TSLP protein and a nucleic acid that encodes that protein. Peptide fragments of the protein that comprise specific epitopes of the canine TSLP protein are also disclosed. The canine TSLP protein and related peptide fragments may be used as an antigen for immunological assays, as well as for vaccines that induce anti-TSLP antibodies. The present invention further discloses methods of making and using the canine TSLP gene, the canine TSLP protein, and the related peptide fragments.
REFERENCES:
patent: 4281061 (1981-07-01), Zuk et al.
patent: 5627043 (1997-05-01), Franzusoff
patent: 5965122 (1999-10-01), Namen et al.
patent: 6555520 (2003-04-01), Sims et al.
patent: 6844170 (2005-01-01), Moore et al.
patent: 7304144 (2007-12-01), Sims et al.
patent: 2002/0068323 (2002-06-01), Saris et al.
patent: 2002/0173623 (2002-11-01), Reche-Gallardo et al.
patent: 2003/0099947 (2003-05-01), Bazan et al.
patent: 2006/0223754 (2006-10-01), Sims et al.
patent: 2010/0021486 (2010-01-01), Hellman
patent: 0314415 (1989-05-01), None
patent: WO 00/29581 (2000-05-01), None
patent: WO 00/39149 (2000-07-01), None
Bendayan, M., “ Possibilities of False Immunocytochemical Results Generated by the Use of Monoclonal Antibodies: The Example of the Anti-proinsulin Antibody,” The Journal of Histochemistry and Cytochemistry, vol. 43(9) pp. 881-886 (1995).
Bost, K., et al., “Antibodies Against a Peptide Sequence Within The HIV Envelope Protein Cross reacts with Human Interleukin-2,” Immunological Investigations, vol. 17(6&7), pp. 577-586 (1988).
Carpino, N., et al., “Absence of an Essential Role for Thymic Stomal Lymphopoietin Receptor in Murine B-Cell Development,” Molecular and Cellular Biology, vol. 24(6), pp. 2584-2592 (2004).
Fry, T., et al., “Interleukin-7: from bench to clinic,” Blood, vol. 99 (11) pp. 3892-3904 (2002).
Gavilondo, J., et al., “Antibody Engineering at the Millennium,” BioTechniques, vol. 29, pp. 128-145 (2000).
Gilliet, M., et al., “Human Dendritic Cells Activated by TSLP and CD40L Induce Proallergic Cytotoxic T Cells,” J. Exp. Med., vol. 197(8), pp. 1059-1063 (2003).
Isaksen, D., et al., “Requirement for Stat5 in Thymic Stromal Lymphopoietin-Mediated Signal Transduction1,” The Journal of Immunology, vol. 163, pp. 5971-5977 (1999).
Janeway, C., “The Immune System in Health and Disease,” Garland Science, 3rdEdition, pp. A:11 (1997).
Leonard, W., et al., “TSLP: finally in the limelight,” Nature Immunology, vol. 3(7) pp. 605-607 (2002).
Liu, Y., “TSLP: An Epithelial Cell Cytokine that Regulates T Cell Differentiation by Conditioning Dendritic Cell Maturation,” Ann. Rev. Immunol. vol. 25 pp. 193-219 (2007).
Liu, Y., “Thymic stromal lymphopoietin: master switch for allergic inflammation,” The Journal of Experimental Medicine, vol, 203(2), pp. 269-273 (2006).
Park, L., et al., “Cloning of the Murine Thymic Stromal Lymphopoietin (TSLP) Receptor: Formation of a Functional Heteromeric Complex Requires Interleukin 7 Receptor,” The Journal of Experimental Medicine, vol. 192(5), pp. 659-669 (2000).
Ray, R., et al., “Characterization of thymic stromal-derived lymphopoietin (TSLP) in murine B cell development in vitro,” Eur. J. Immunol. vol. 26, pp. 10-16 (1996).
Reche, P., et al., “Human Thymic Stromal Lymphopoietin Preferentially Stimulates Myeloid Cells,” The Journal of Immunology, vol. 167, pp. 336-343 (2001).
Rochman, I., et al., “Cutting Edge: Direct Action of Thymic Stromal Lymphopoietin on Activated Human CD4+T Cells”, The Journal of Immunology, vol. 178 pp. 6720-6724 (2007).
Sims, J., et al., “Molecular Cloning and Biological Characterization of a Novel Murine Lymphoid Growth Factor”, The Journal of Experimental Medicine, vol. 192, No. 5, pp. 671-680 (2000).
Soumelis, V., et al., “Human epithelial cells trigger dendritic cell-mediated allergic inflammation by producing TSLP,” Nature Immunology, vol. 3(7), pp. 673-680 (2002).
Soumelis, V., et al., “Human thymic stromal lymphopoietin: a novel epithelial cell-derived cytokine and a potential key player in the induction of allergic inflammation,” Springer Semi Immun., vol. 25, pp. 325-333 (2004).
Voβhenrich, C., et al., “Thymic stromal-derived lymphopoietin distinguishes fetal from adult B cell development,” Nature Immunology, vol. 4(8) pp. 773-779 (2003).
Wang, J., et al., “Human TSLP-Educated DCs,” Cellular & Molecular Immunology, vol. 5(2), pp. 99-106 (2008).
Watanabe, N., et al., “Human TSLP promotes CD40 ligand-induced IL-12 production by myeloid dendritic cells but maintains their Th2 priming potential,” Blood, vol. 105(12) pp. 4749-4751 (2005).
Watanabe, N., et al., “Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4+T cell homeostatic expansion,” Nature Immunology, vol. 5(4) pp. 426-434 (2005).
Zhou, B., et al., “Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice,” Nature Immunology, vol. 6(10) pp. 1047-1053 (2005).
Ziegler, S., et al. “Thymic stromal lymphopoietin in normal and pathogenic T cell development and function,” Nature Immunology, vol. 7(7), pp. 709-714 (2006).
Valenzona et al., “Exogenous Interleukin 7 as a Proliferative Stimulant of Early Precursor B Cells in Mouse Bone Marrow: Efficacy of IL-7 Injection, IL-7 Infusion and IL-7-Anti-IL-7 Antibody Complexes,” Cytokine, vol. 10, No. 6, pp. 404-412 (Jun. 1998).
Miyaji, et al., “A Comparison of Proliferative Response to IL-7 and Expression of IL-7 Receptors in Intermediate TCR Cells of the Liver, Spleen, and Thymus,” Cellular Immunology vol. 169, Article 0106, pp. 159-165 (1996).
Pearson, et al., “Effective Protein Sequence Comparison,” Methods in Enzymology, vol. 266, pp. 227-258 (1996).
Mott, et al., “Four-Helix Bundle Growth Factors and Their Receptors: Protein-Protein Interactions,” Current Opinion in Structural Biology, vol. 5, No. 1, pp. 114-121 (1995).
Kroemer, et al., “Prediction of the Three-Dimensional Structure of Human Interleukin-7 by Homology Modeling,” Protein Engineering, vol. 9, No. 6, pp. 493-498 (1996).
Winkler, et al., “Interleukin-3 and Interleukin-7 Are Alternative Growth Factors for the Same B-Cell Precursors in the Mouse,” Blood, vol. 85, pp. 2045-2051 (1995).
Al-Shami, et al., “A Role for Thymic Stromal Lymphopoietin in CD4+ T Cell Development,” The Journal of Experimental Medicine, vol. 200, No. 2, pp. 159-168 (2004).
Cosenza, et al., “Disulfide Bond Assignment in Human Interleukin-7 by Matrix-Assisted Laser Desorption/Ionization Mass Spectroscopy and Site-Directed Cysteine to Serine Mutational Analysis,” The Journal of Biological Chemistry, vol. 272, No. 52, pp. 32995-33000 (1997).
Kruse, et al., “Two Distinct Functional Sites of Human Interleukin 4 are Identified by Variants Impaired in Either Receptor Binding or Receptor Activation,” The EMBO Journal, vol. 12, No. 13, pp. 5121-5129 (1993).
Levin, Steven D., et al., Journal of Immunology, “Thymic Stromal Lymphoprotein: A cytokine that promotes the development of IgM+ B cells in Vitro and Signals via a novel mechanism,” (Jan. 1999), pp. 677-683, vol. 162.
Mahairas, G.G., et al., GenBank, Accession No. AQ781833, (Aug. 2, 1999), Definition: “HS—3148—A2—C03—T7C CIT Approved Human Genomic Sperm Library DHomo sapiensgenomic clone Plate=3148 Col=6 Row=E, genomic survey sequence.”
Maeurer, Markus J., et al., The Cytokine Handbook, 3rd ed., “Interleukin-7,” (1998), Ch. 9:229-269. Thomson, ed.(Academic Press, Inc., San Diego, California).
Marra, M., et al., GenBank, Accession No. AA717930, (Dec. 29, 1997), Definition: “vt09f05.r1 Barstead mouse myotubes MPLRB5Mus musculu
de Waal Malefyt Rene
Gorman Daniel M.
Mattson Jeanine D.
Morsey Mohamad A.
Intervet Inc.
Landsman Robert
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