Fusion proteins

Details Fusion proteins Fusion proteins

1995-06-06

1997-12-23

Guzo, David

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4352542, 4353201, 536 234, 536 237, 536 2372, C12N 510, C12N 1586, C07H 2104

Patent

active

057006806

ABSTRACT:
A DNA sequence encoding a fusion protein comprising influenza virus HA, at a site of which normally occupied by a natural antigenic epitope thereof a different antigenic epitope is provided, is incorporated in a vector which is capable of expressing the fusion protein when provided in a eucaryotic host. When in the form of a viral vector such as a recombinant vaccinia virus, the vector can be used as a vaccine. Alternatively, the fusion protein expressed by the host can be recovered and provided as a vaccine.

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