Fusion protein of porcine reproductive and respiratory...

Details Fusion protein of porcine reproductive and respiratory... Fusion protein of porcine reproductive and respiratory...

2006-07-05

2008-12-16

Salimi, Ali R. (Department: 1648)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

C435S006120

Reexamination Certificate

active

07465455

ABSTRACT:
A fusion protein of porcine reproductive and respiratory syndrome virus (PRRSV) for PRRSV vaccine. The fusion protein includes: (a) a Pseudomoitas Exoloxin A (PE) peptide that comprises a binding domain and a translocating domain; (b) a peptide fragment that contains a N-terminal portion of PRRSV ORF6 protein; (c) a peptide fragment that has a N-terminal portion of PRRSV ORF5 protein; and (d) a carboxyl terminal domain that comprises an amino acid seciuence KDEL. The PE peptide is located at the N-terminus of the fusion protein, and the peptide fraament containinC the N-terminal portion of PRRSV ORF5 protein is located between the peptide fragment containing the N-terminal portion of PRRSV ORF6 protein and the carboxyl terminal domain.

REFERENCES:
patent: 2004/0247617 (2004-12-01), Liao et al.
patent: 2008/0019912 (2008-01-01), Harris et al.
Ansari et al. Journal of Virology, Apr. 2006, vol. 80, No. 8, pp. 3994-4004.
Eric J. Snijder et al., “Heterodimerization of the Two Major Envelope Proteins Is Essential for Arterivirus Infectivity”, Journal of Virology, Jan. 2003, p. 97-104.
M:. Ostrowski et al., “Identification of Neutralizing and Nonneutralizing Epitopes in the Porcine Reproductive and Respiratory Syndrome Virus GP5 Ectodomain”, Journal of Virology, May 2002, p. 4241-4250.

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