Fusion protein for inhibiting cervical cancer

Details Fusion protein for inhibiting cervical cancer Fusion protein for inhibiting cervical cancer

2005-08-18

2008-05-27

Salimi, Ali R. (Department: 1648)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

C435S006120

Reexamination Certificate

active

07378100

ABSTRACT:
A fusion protein for inhibiting cervical cancer is disclosed, which comprises a peptide sequence of human papillomavirus type 16, a peptide translocating peptide for translocation, and a peptide within a carboxyl terminal fragment. The present invention further comprising a composition of antibody, which conjugates to E7 peptide, wherein the nucleotide sequence corresponding to the amino acid sequence of the E7 peptide is shown as SEQ. ID. NO.1.

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Hung et al. Cancer Research, May 2001, vol. 61, pp. 3698-3703.
Y.Qin, et al. “Human papillomavirus type 16 E7 peptide38-61 linked with an immunoglobulin G fragment provides protective immunity in mice”, Gynecologic Oncology, 2005, vol. 96, pp. 475-483.
C. Liao, et al., “Fusion Protein Vaccine by Domains of Bacterial Exotoxin Linked with a Tumor Antigen Generates Potent Immunologic Responses and Antitumor Effects”, Cancer Res, 2005, vol. 65, No. 19, pp. 9089-9098.

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