Chemistry: analytical and immunological testing – Sulfur containing – Organic or sulfhydryl containing
Reexamination Certificate
2006-06-27
2006-06-27
Ponnaluri, Padmashri (Department: 1639)
Chemistry: analytical and immunological testing
Sulfur containing
Organic or sulfhydryl containing
C436S119000, C435S004000, C435S007100, C435S007200, C435S091500, C568S018000, C568S029000
Reexamination Certificate
active
07067322
ABSTRACT:
Disclosed are methods for making surface plasmon resonance-capable arrays wherein molecules, such as proteins or nucleic acids, or cells, are adhered to a metal substrate. The metal substrates are modified by depositing an ω-modified alkanethiol monolayer to the substrate and then contacting the ω-modified monolayer with a heterobifunctional linking compound. Biomolecules or cells can then be attached to the heterobifunctional linking compound. Also disclosed are arrays wherein glutathione-containing molecules are immobilized on the substrate and GST-containing molecules are then specifically immobilized onto the substrate, taking advantage of the affinity between glutathione and GST.
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Corn Robert M.
Erickson Matthew G.
Smith Emily A.
Ulijasz Andrew T.
Wanat Matthew J.
DeWitt Ross & Stevens S.C.
Leone, Esq. Joseph T.
Ponnaluri Padmashri
Tran My-Chau T.
Wisconsin Alumni Research Foundation
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