Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1995-06-05
1999-11-16
Naff, David M.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
424422, 424520, 4351723, 435174, 435180, 435181, 514 2, 530300, 530353, 530395, 530402, 530810, 530815, C07K 100, C07K 1702, C12N 1500, C12N 1102
Patent
active
059860529
ABSTRACT:
Link protein and cartilage matrix protein, which are two major components of the extracellular cartilage matrix, have been found to bind to each other. Polypeptide fragments of cartilage matrix protein and link protein are produced. A recombinant fusion polypeptide is prepared containing a fragment of cartilage matrix protein that binds to link protein and a fragment of link protein that binds to cartilage matrix protein. The cartilage matrix protein fragment may bind to collagen and contain the CMP-1 or CMP-2 domain, and the link protein may bind to a complex of hyaluronic acid and proteoglycan. The fragments or fusion polypeptide can be administered for repair of diseased or injured cartilaginous and non-cartilaginous tissue by promoting binding of a complex of proteoglycan and hyaluronic acid to collagen. The fragments or fusion polypeptide can be anchored to the surface of a prosthetic device, implant or tissue graft to promote adherence of tissue and biocompatibility. By anchoring a fragment of cartilage matrix protein or link protein on a surface, cartilaginous tissue, cartilage matrix protein or link protein may be attached to the surface.
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Binette Francois
Goetinck Paul F.
Tondravi M. Mehrdad
Naff David M.
The General Hospital Corporation
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