Fusion peptide containing human type-1 collagen derived...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fusion protein or fusion polypeptide

Reexamination Certificate

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C435S069100, C530S327000, C530S328000, C514S014800, C514S016700, C514S844000, C514S947000

Reexamination Certificate

active

07094407

ABSTRACT:
The present invention relates to a fusion peptide, in which a self cell-penetrating Tat peptide having a self penetrating signal is bound to a human Type-I collagen C-terminal derived peptide, a preparation thereof, and a skin anti-aging cosmetic composition comprising the same. Since the fusion peptide, in which the Tat peptide is bound to the human Type-collagen C-terminal derived peptide is highly stable and has a superior skin absorption capability, the present invention provides a skin anti-aging agent having superior synthesis of collagen and hyaluronic acid, anti-aging effects, and improved durability of the effects.

REFERENCES:
patent: 6444647 (2002-09-01), Robinson et al.
patent: 6620419 (2003-09-01), Lintner
patent: 2094658 (1993-10-01), None
patent: WO 97/18235 (1997-05-01), None
patent: WO 00/15188 (2000-03-01), None
Schwarze et al., Science, vol. 285, No. 5433, pp. 1569-1572 (1999).
Fawell et al., Cell Biology, vol. 91, pp. 664-668 (Jan. 1994).
Singh et al., Proceed. Intern. Symp. Control. Ref. Bioact. Mater., vol. 20, pp. 107-108, (1993).
Jin et al., Free Radical Biology & Medicine, vol. 31, No. 11, pp. 1509-1519 (2001).
Abstract of JP 2001-163758 A2, Jun. 19, 2001.
Abstract of JP 10-298196 A2, Nov. 10, 1998.
Abstract of JP 09-295930 A2, Nov. 18, 1997.
Abstract of JP 04-090844 A2, Mar. 24, 1992.

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