Fusion partner for production of monoclonal rabbit antibodies

Details Fusion partner for production of monoclonal rabbit antibodies Fusion partner for production of monoclonal rabbit antibodies

2008-08-21

2010-06-08

Gambel, Phillip (Department: 1644)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

C435S070100, C435S070200, C435S069100, C435S326000

Reexamination Certificate

active

07732168

ABSTRACT:
The invention provides a rabbit-derived immortal B-lymphocyte capable of fusion with a rabbit splenocyte to produce a hybrid cell that produces an antibody. The immortal B-lymphocyte does not detectably express endogenous immunoglobulin heavy chain and may contain, in certain embodiments, an altered immunoglobulin heavy chain-encoding gene. A hybridoma resulting from fusion between the subject immortal B-lymphocyte and a rabbit antibody-producing cell is provided, as is a method of using that hybridoma to produce an antibody. The subject invention finds use in a variety of different diagnostic, therapeutic and research applications.

REFERENCES:
patent: 5675063 (1997-10-01), Knight
Rief et al., “Production and Characterization of a Rabbit Monoclonal Antibody Against Human CDC25C Phosphatase”, Hybridoma (1998), 17(4), pp. 389-394.
Spieker-Polet et al., “Rabbit Monoclonal Antibodies: Generating A Fusion Partner to Produce Rabbit-Rabbit Hybridomas”, Proc. Natl. Acad. Sci. USA. (1995), 26:92(20); pp. 9348-9352.
Liguori et al., “Recombinant Human Interleukin-6 Enhances the Immunoglobulin Secretion of a Rabbit-Rabbit Hybridoma”, (2001), 20(3), pp. 189-198.

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