Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...
Reexamination Certificate
2006-06-27
2008-09-30
Gambel, Phillip (Department: 1644)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Animal cell, per se, expressing immunoglobulin, antibody, or...
C435S328000
Reexamination Certificate
active
07429487
ABSTRACT:
The invention provides a rabbit-derived immortal B-lymphocyte capable of fusion with a rabbit splenocyte to produce a hybrid cell that produces an antibody. The immortal B-lymphocyte does not detectably express endogenous immunoglobulin heavy chain and may contain, in certain embodiments, an altered immunoglobulin heavy chain-encoding gene. A hybridoma resulting from fusion between the subject immortal B-lymphocyte and a rabbit antibody-producing cell is provided, as is a method of using that hybridoma to produce an antibody. The subject invention finds use in a variety of different diagnostic, therapeutic and research applications.
REFERENCES:
patent: 5675063 (1997-10-01), Knight
Rief et al., “Production and Characterization of a Rabbit Monocional Antibody Against Human CDC25C Phosphatase”, Hybridoma (1998), 17(4), pp. 389-394.
Spieker-Polet et al., “Rabbit Monoclonal Antibodies: Generating A Fusion Partner to Produce Rabbit-Rabbit Hybridomas”, Proc. Natl. Acad. Sci. USA. (1995), 26:92(20); pp. 9348-9352.
Liguori et al., “Recombinant Human Interleukin-6 Enhances the Immunoglobulin Secretion of a Rabbit-Rabbit Hybridoma”, (2001), 20(3), pp. 189-198.
Au Harry C.
Ke Yaohuang
Pytela Robert
Qian Qi
Zhu Weimin
Bozicevic Field & Francis LLP
Epitomics, Inc.
Gambel Phillip
Keddie James S.
Wen Sharon
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