Fused-ring pyridine derivative, process for producing the...

Details Fused-ring pyridine derivative, process for producing the... Fused-ring pyridine derivative, process for producing the...

2007-10-30

2007-10-30

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

10544435

ABSTRACT:
The present invention provides a compound represented by the formula:wherein R1is a 5- or 6-membered ring which may be substituted;R3is a hydrogen atom, a lower alkyl group or a lower alkoxy group;Z1is a 5- or 6-membered aromatic ring;Z2is a group represented by -Z2a-W2-Z2bwherein Z2aand Z2bare each O, S(O)m(wherein m is 0, 1 or 2), an imino group, or a bond; and W2is an alkylene chain which may be substituted;n is an integer of 0 to 4;Y is O, S(O)p(wherein p is 0, 1 or 2), CH2or NR4(wherein R4is a hydrogen atom, a hydrocarbon group, a heterocyclic group, or an acyl group); andR2is (1) an amino group, in which the nitrogen atom is converted to quaternary ammonium or oxide, (2) a nitrogen-containing heterocyclic group which may contain a sulfur atom or an oxygen atom as a ring-constituting atom, in which the nitrogen atom may be converted to a quaternary ammonium or an oxide, and the like, or a salt thereof.The compound has excellent CCR5 antagonist activity and is useful as a prophylactic and/or therapeutic medicine for HIV infection in human peripheral mononuclear blood cells, especially AIDS.

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