Fused-ring heterocycles for the treatment of atherosclerosis

Details Fused-ring heterocycles for the treatment of atherosclerosis Fused-ring heterocycles for the treatment of atherosclerosis

1992-05-29

1995-12-26

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544262, 544264, 544276, 544277, 544271, 544272, 546118, 546119, C07D48704, A61K 31505, A61K 3152, A61K 3144

Patent

active

054788307

ABSTRACT:
This invention relates to pyrazolo pyrimidines for the treatment of atherosclerosis as inhibitors of acyl--CoA, cholesterol acyetransferase (ACAT), and their use as antihypercholesterolemic agents, pharmaceutical compositions and preparation, and having the formula (I): ##STR1## wherein: A and Q are selected independently from CH or N with no more than two nitrogens per ring:

REFERENCES:
Noell, JO.sub.vg Chem 23, 1547 (1958).

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