Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-04-24
1997-01-07
Haley, Jacqueline
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546 22, 5462767, 548417, 548110, 548103, C07D48706
Patent
active
055918557
ABSTRACT:
Disclosed herein are compounds referred to as "fused pyrrolocarbazoles" which possess a variety of functional activities. The disclosed compounds are represented by the following general formula: ##STR1## Methodologies for the synthetic production of fused pyrrolocarbazoles are also disclosed, as well as exemplary uses of the compounds.
REFERENCES:
patent: 4552842 (1985-11-01), Nettleton, Jr. et al.
patent: 4912107 (1990-03-01), Kleinschroth et al.
patent: 4923986 (1990-05-01), Murakata et al.
patent: 5057614 (1991-10-01), Davis et al.
patent: 5185260 (1993-02-01), Crissman et al.
patent: 5405864 (1995-04-01), Broka
Bergman et al, "Coupling of Indoleacetic Acid trianion or Methyl Indoleacetic Acid Dianion. A Biomimetic Approach to Indolocarbazole Alkaloids," Tetrahedron Letters, vol. 28, No. 38, pp. 4441-4444 (1987).
Bit et al., "Inhibitors of Protein Kinase C 3. Potent and Highly Selective Bisindolylmaleimides by Conformational Restriction," J. Med. Chem. 36:21-29 (1993).
Bozyczko-Coyne et al., "A rapid fluoremetric assay to measure neuronal survival in vitro," Journal of Neuroscience Methods 50:205-216 (1993).
Brenner et al., "Synthesis of Arcyriarubin B and Related Bisindolylmaleimides," Tetrahedron 44:2887-2892 (1988).
Buu-Hol et al., "Carcinogenic Nitrogen Compounds," J. Chem. Soc. (1956) 1515-1518.
Davis et al., "Potent selective inhibitors of protein kinase C," FEBS Letters, vol. 259, No. 1, pp. 61-63 (1989).
Davis et al., "A Convenient Synthesis of Bisindolyl-- and Indolylaryl-Maleic Anhydrides,"Tetrahedron Letters, vol. 31, No. 16, pp. 2353-2356 (1990).
Davis et al., "A Mild Conversionof maleic Anhydrides into Maleimides," Tetrahedron Letters, vol. 31, No. 36, pp. 5201-5204 (1990).
Davis et al, "Inhibitors of Protein Kinase C. 1. 1 2,3-Bisarylamaleimdes," J. Med. Chem. 35:177-184 (1992).
Davis et al., "Inhibitors of Protein Kinase C. 2. Substuted Bisindolylmaleimides with Improved Potency and Selectivity," J. Med. Chem. 35:994-1001 (1992).
Davis et al., "The Design of Inhibitors of Protein Kinase C; The Solution Conformation of Staurosporine," J. Chem. Soc., Chem. Commun. pp. 182-184 (1991).
Fraser, "Expression of Eucaryotic Genesin Insect Cell Cultures," In Vitro Cellular & Developmental Biology (1989) 25:225-235.
Gallant et al., "A Steroeoselective Synthesis of Indol-.beta.-N-glycosides: An application to the Synthesis of Rebeccamycin," J. Org. Chem. 58:343-349 (1993).
Hallb ook, et al., Evolutionary Studiesof the Nerve Growth Factor Family Reveal a Novel Member Abundantly Expressed in Xenopus Ovary, Neuron, (1991) 6:845-858.
Hara et al., Staurosporine, a Novel Protein kinase C Inhibitor, Prevents Postischemic Neuronal Damage in the Gerbil and Rat, Journal of Cerebral Blood Flow and Metabolism (1990) 10:646-653.
Hendricks et al., "2-Aryl-Indolyl Maleimides-Novel and Potetn Inhibitors of Protein Kinase C," Biorganic & Medicinal Chemistry Letters, vol. 5, No. 1, pp. 67-72 (1995).
Hughes et al., "Synthesis of Arcyriaflavin B," Tetrahedron Letters, vol. 24, No. 13, pp. 1441-1444 (1983).
Hughes et al., "Synthesis of the Indo[2,3-a]carbazole Natural Products Staurosporinone and Arcyriaflavin B," J. Chem. Soc. Perkin Trans. 1 pp. 2475-2480 (1990).
Kamiya Biomedical Co., Product List (1993). Thousand Oaks, CA.
Kaneko et al. "Two Synthetic approaches to Rebeccamycin," tetrahedron Letters, vol. 26, No. 34, pp. 4015-4018 (1985).
Kikkawa et al., Calcium-activated, Phospholipid-dependent Protein Kinase from Rat Brain, The Journal of Biological Chemistry (1982) 257:13341-13348.
Link et al.,"The First Synthesis of a Fully Functionalized core structre of Staurosporine: Sequential Indoly Glycosidation by Endo and Exo Glycals," J. Am. Chem. Soc., 115:3782-3783 (1993).
Magnue et al., "Indole-2,3-Quinodimethanes," Tetrahedron, vol. 40, No. 14, pp. 2795-2797 (1984).
Meyer et al., "Production and Characterization of Recombinant Mouse Brain-Derived Neurotrophic Factor and Rat Neurotrophin-3 Expressed in Insect Cells," Journal of neurochemistry (1994) 62:825-833.
Moody et al., "Synthesis of the Staurosporine Aglycon," J. Org. Chem. 57:2205-2114 (1992).
Muid et al.,"A novel conformatinally restricted protein kinase C inhibitor Ro 31-8425, inhibits human neutrophil . . . post-receptor stimuli," FEBS vol 293, No. 1,2 pp. 169-172 (1991).
Mulqueen et al., "Oral, anti-inflammatory activity of a potent, selective, protein kinase C inhibitor," Agents Action, 37:85-89 (1992).
Nabeshima et al., "Staurosporine, a protein kinase inhibior, attenuates basal forebrain-lesion-induced amnesia and cholinergic neuronal deficit", Neuroscience Letters (1990) 122:13-16.
Pflug et al., J. Cell Biochem. Suppl. 18D Abstract Y215 (1994).
Phelps et al., "Generation Patterns of Four Groups of Cholinergic Neurons in Rat Cervical Spinal Cord: A Combined Tritiated . . . Study", The Journal of Comparative Neurology (1988) 273:459-472.
Sarstedt et al., "Reactions with Indole Derivatives, ILVIII," Heterocycles, vol. 20, No. 3, pp. 469-476 (1983).
Smith et al., "Trophic Effects of Skeletal Muscle Extracts on Ventral Sprinal Cord Neurons in Vitro: Separation . . . Proteins with Cholinergic Activity", The Journal of Cell Biology (1995) 101:1608-1621.
Tollec et al., "The Bisindolylmaleimide FG 109203X is a Potent and Selective Inhibitor of Protein Kinase C.," J. Biol. Chem., vol. 266, No. 24, pp. 15771-15781 (1991).
Hudkins Robert L.
Knight, Jr. Ernest
Cephalon Inc.
Haley Jacqueline
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