Fused pyrrolocarbazoles

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

546 22, 5462767, 548417, 548110, 548103, C07D48706

Patent

active

055918557

ABSTRACT:
Disclosed herein are compounds referred to as "fused pyrrolocarbazoles" which possess a variety of functional activities. The disclosed compounds are represented by the following general formula: ##STR1## Methodologies for the synthetic production of fused pyrrolocarbazoles are also disclosed, as well as exemplary uses of the compounds.

REFERENCES:
patent: 4552842 (1985-11-01), Nettleton, Jr. et al.
patent: 4912107 (1990-03-01), Kleinschroth et al.
patent: 4923986 (1990-05-01), Murakata et al.
patent: 5057614 (1991-10-01), Davis et al.
patent: 5185260 (1993-02-01), Crissman et al.
patent: 5405864 (1995-04-01), Broka
Bergman et al, "Coupling of Indoleacetic Acid trianion or Methyl Indoleacetic Acid Dianion. A Biomimetic Approach to Indolocarbazole Alkaloids," Tetrahedron Letters, vol. 28, No. 38, pp. 4441-4444 (1987).
Bit et al., "Inhibitors of Protein Kinase C 3. Potent and Highly Selective Bisindolylmaleimides by Conformational Restriction," J. Med. Chem. 36:21-29 (1993).
Bozyczko-Coyne et al., "A rapid fluoremetric assay to measure neuronal survival in vitro," Journal of Neuroscience Methods 50:205-216 (1993).
Brenner et al., "Synthesis of Arcyriarubin B and Related Bisindolylmaleimides," Tetrahedron 44:2887-2892 (1988).
Buu-Hol et al., "Carcinogenic Nitrogen Compounds," J. Chem. Soc. (1956) 1515-1518.
Davis et al., "Potent selective inhibitors of protein kinase C," FEBS Letters, vol. 259, No. 1, pp. 61-63 (1989).
Davis et al., "A Convenient Synthesis of Bisindolyl-- and Indolylaryl-Maleic Anhydrides,"Tetrahedron Letters, vol. 31, No. 16, pp. 2353-2356 (1990).
Davis et al., "A Mild Conversionof maleic Anhydrides into Maleimides," Tetrahedron Letters, vol. 31, No. 36, pp. 5201-5204 (1990).
Davis et al, "Inhibitors of Protein Kinase C. 1. 1 2,3-Bisarylamaleimdes," J. Med. Chem. 35:177-184 (1992).
Davis et al., "Inhibitors of Protein Kinase C. 2. Substuted Bisindolylmaleimides with Improved Potency and Selectivity," J. Med. Chem. 35:994-1001 (1992).
Davis et al., "The Design of Inhibitors of Protein Kinase C; The Solution Conformation of Staurosporine," J. Chem. Soc., Chem. Commun. pp. 182-184 (1991).
Fraser, "Expression of Eucaryotic Genesin Insect Cell Cultures," In Vitro Cellular & Developmental Biology (1989) 25:225-235.
Gallant et al., "A Steroeoselective Synthesis of Indol-.beta.-N-glycosides: An application to the Synthesis of Rebeccamycin," J. Org. Chem. 58:343-349 (1993).
Hallb ook, et al., Evolutionary Studiesof the Nerve Growth Factor Family Reveal a Novel Member Abundantly Expressed in Xenopus Ovary, Neuron, (1991) 6:845-858.
Hara et al., Staurosporine, a Novel Protein kinase C Inhibitor, Prevents Postischemic Neuronal Damage in the Gerbil and Rat, Journal of Cerebral Blood Flow and Metabolism (1990) 10:646-653.
Hendricks et al., "2-Aryl-Indolyl Maleimides-Novel and Potetn Inhibitors of Protein Kinase C," Biorganic & Medicinal Chemistry Letters, vol. 5, No. 1, pp. 67-72 (1995).
Hughes et al., "Synthesis of Arcyriaflavin B," Tetrahedron Letters, vol. 24, No. 13, pp. 1441-1444 (1983).
Hughes et al., "Synthesis of the Indo[2,3-a]carbazole Natural Products Staurosporinone and Arcyriaflavin B," J. Chem. Soc. Perkin Trans. 1 pp. 2475-2480 (1990).
Kamiya Biomedical Co., Product List (1993). Thousand Oaks, CA.
Kaneko et al. "Two Synthetic approaches to Rebeccamycin," tetrahedron Letters, vol. 26, No. 34, pp. 4015-4018 (1985).
Kikkawa et al., Calcium-activated, Phospholipid-dependent Protein Kinase from Rat Brain, The Journal of Biological Chemistry (1982) 257:13341-13348.
Link et al.,"The First Synthesis of a Fully Functionalized core structre of Staurosporine: Sequential Indoly Glycosidation by Endo and Exo Glycals," J. Am. Chem. Soc., 115:3782-3783 (1993).
Magnue et al., "Indole-2,3-Quinodimethanes," Tetrahedron, vol. 40, No. 14, pp. 2795-2797 (1984).
Meyer et al., "Production and Characterization of Recombinant Mouse Brain-Derived Neurotrophic Factor and Rat Neurotrophin-3 Expressed in Insect Cells," Journal of neurochemistry (1994) 62:825-833.
Moody et al., "Synthesis of the Staurosporine Aglycon," J. Org. Chem. 57:2205-2114 (1992).
Muid et al.,"A novel conformatinally restricted protein kinase C inhibitor Ro 31-8425, inhibits human neutrophil . . . post-receptor stimuli," FEBS vol 293, No. 1,2 pp. 169-172 (1991).
Mulqueen et al., "Oral, anti-inflammatory activity of a potent, selective, protein kinase C inhibitor," Agents Action, 37:85-89 (1992).
Nabeshima et al., "Staurosporine, a protein kinase inhibior, attenuates basal forebrain-lesion-induced amnesia and cholinergic neuronal deficit", Neuroscience Letters (1990) 122:13-16.
Pflug et al., J. Cell Biochem. Suppl. 18D Abstract Y215 (1994).
Phelps et al., "Generation Patterns of Four Groups of Cholinergic Neurons in Rat Cervical Spinal Cord: A Combined Tritiated . . . Study", The Journal of Comparative Neurology (1988) 273:459-472.
Sarstedt et al., "Reactions with Indole Derivatives, ILVIII," Heterocycles, vol. 20, No. 3, pp. 469-476 (1983).
Smith et al., "Trophic Effects of Skeletal Muscle Extracts on Ventral Sprinal Cord Neurons in Vitro: Separation . . . Proteins with Cholinergic Activity", The Journal of Cell Biology (1995) 101:1608-1621.
Tollec et al., "The Bisindolylmaleimide FG 109203X is a Potent and Selective Inhibitor of Protein Kinase C.," J. Biol. Chem., vol. 266, No. 24, pp. 15771-15781 (1991).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Fused pyrrolocarbazoles does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fused pyrrolocarbazoles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fused pyrrolocarbazoles will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1765389

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.