Fused Pyrrolocarbazoles

Details Fused Pyrrolocarbazoles Fused Pyrrolocarbazoles

1994-10-14

1995-12-12

Haley, Jacqueline

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546271, 548417, C07D48706

Patent

active

054751101

ABSTRACT:
Disclosed herein are compounds referred to as "fused pyrrolocarbazoles" which possess a variety of functional activities. The disclosed compounds are represented by the following general formula: ##STR1## Methodologies for the synthetic production of fused pyrrolocarbazoles are also disclosed, as well as exemplary uses of the compounds.

REFERENCES:
patent: 4552842 (1985-11-01), Nettleton, Jr. et al.
patent: 4912107 (1990-03-01), Kleinschroth et al.
patent: 4923986 (1990-05-01), Murakata et al.
patent: 5057614 (1991-10-01), Davis et al.
patent: 5185260 (1993-02-01), Crissman et al.
patent: 5405864 (1995-04-01), Broka
Bozyczko-Coyne et al., A rapid fluorometric assay to measure neuronal survival in vitro, Journal of Neuroscience Methods 50(1993) pp. 205-216.
Buu-Hol; et al., Carcinogenic Nitrogen Compounds, J. Chem. Soc. (1956) pp. 1515-1518.
Fraser, Expression of Eucaryotic Genes in Insect Cell Cultures, In Vitro Cellular & Developmental Biology vol. 25, No. 3, (1989) pp. 225-235.
Hallbook, et al., Evolutionary Studies of the Nerve Growth Factor Family Reveal a Novel Member Abundantly Expressed in Xenopus Ovary, Nuron, vol. 6 (1991) pp. 845-858.
Hara et al., Staurosporine, a Novel Protein Kinase C Inhibitor, Prevents Postischemic Neuronal Damage in the Gerbil and Rat, Journal of Cerebral Blood Flow and Metabolism (1990) 10:646-653.
Kamiya Biomedical Co., Product List (1993) Thousand Oaks, Calif.
Kikkawa et al., Calcium-activated, Phospholipid-dependent Protein Kinase from Rat Brain, The Journal of Biological Chemistry (1982) vol. 257 No. 22 pp. 13341-13348.
Meyer et al., Production and Characterization of Recombinant Mouse Brain-Derived Neurotrophic Factor and Rat Neurotrophin-3 Expressed in Insect Cells, Journal of Neurochemistry (1994) pp. 825-832.
Nabeshima et al., Staurosporine, a protein kinase inhibitor, attenuates basal forebrain-lesion-induced amnesia and cholinergic neuronal deficit, Neuroscience Letters (1990) vol. 122 pp. 13-16.
Pflug et al., J. Cell. Biochem. Suppl. 18D Abstract Y215 (1994).
Phelps et al., Generation Patterns of Four Groups of Cholinergic Neurons in Rat Cervical Spinal Cord: A Combined Tritiated Thymidine Autoradiographic and Choline Acetyltransferse Immunocytochemical Study The Journal of Comparative Neurology (1988) 273:459-472.
Smith et al., Trophic Effects of Skeletal Muscle Extracts on Ventral Spinal Cord Neurons in Vitro: Separation of a Protein with Morphologic Acivity from Proteins with Cholinergic Activity, The Journal of Cell Biology, (1985) vol. 101 pp. 1608-1621.
Bergman et al., "Coupling of Indoleacetic Acid Trianion or Methyl Indoleacetic Acid Dianion. A Biomimetic Approach to Indolocarbazole Alkaloids," Tetrahedron Letters, vol. 28, No. 38, pp. 4441-4444 (1987).
Bit et al., "Inhibitors of Protein Kinase C. 3. Potent and Highly Selective Bisindolylmaleimides by Conformational Restriction," J. Med. Chem. 36:21-29 (1993).
Brenner et al., "Synthesis of Arcyriarubin B and Related Bisindolylmaleimides, " Tetrahedron vol. 44, vol. 10, pp. 2887-2892 (1988).
Davis et al., "Potent selective inhibitors of protein kinase C, " FEBS Letters, vol. 259, No. 1, pp. 61-63 (1989).
Davis et al., "Inhibitors of Protein Kinase C. 2. Substituted Bisindolylmaleimides with Improved Potency and Selectivity," J. Med. Chem. 35:994-1001 (1992).
Davis et al., "A Convenient Synthesis of Bisindolyl-and Indolylaryl-Maleic Anhydrides," Tetrahedron Letters, vol. 31, No. 16, pp. 2353-2356 (1990).
Davis et al., "A Mild Conversion of Maleic Anhydrides into Maleimides," Tetrahedron Letters, vol. 31, No. 36, pp. 5201-5204 (1990).
Davis et al., "The Design of Inhibitors of Protein Kinase C; The solution Conformation of Staurosporine," J. Chem. Soc., Chem. Commun. pp. 182-184 (1991).
Davis et al., "Inhibitors of Protein Kinase C. 1.1 2,3-Bisarylamaleimides," J. Med. Chem. 35:177-184 (1992).
Davis et al., "Inhibitors of Protein Kinase C. 2. Substituted Bisindolylmaleimides with Improved Potency and Selectivity," J. Med. Chem. 35:994-1001 (1992).
Gallant et al., "A Stereoselective Synthesis of Indole-.beta.-N-glycosides: An Application to the Synthesis of Rebeccamycin," J. Org. Chem. 58:343-349 (1993).
Hendricks et al., "2-Aryl-Indolyl Maleimides-Novel and Potent Inhibitors of Protein Kinase C," Biorganic & Medicinal Chemistry Letters, vol. 5, No. 1, pp. 67-72 (1995).
Hughes et al., "Synthesis of Arcyriaflavin B," Tetrahedron Letters, vol. 24, No. 13, pp. 1441-1444 (1983).
Hughes et al., "Synthesis of the Indolo[2,3--a]carbazole Natural Products Staurosporinone and Arcyriaflavin B," J. Chem. Soc. Perkin Trans. 1 pp. 2475-2480 (1990).
Kaneko et al., "Two Synthetic Approaches to Rebeccamycin," Tetrahedron Letters, vol. 26, No. 34, pp. 4015-4018 (1985).
Link et al., "The First Synthesis of a Fully Functionalized Core Structure of Staurosporine: Sequential Indolyl Glycosidation by Endo and Exo Glycals," J. Am. Chem. Soc. 115:3782-3783 (1993).
Magnus et al., "Indole-2,3-Quinodimethanes," Tetrahedron, vol. 40, No. 14, pp. 2795-2797 (1984).
Moody et al., "Synthesis of the Staurosporine Aglycon," J. Org. Chem. 57:2105-2114 (1992).
Muid et al., "A novel conformationally restricted protein kinase C inhibitor Ro 31-8425, inhibits human neutrophil . . . post-receptor stimuli," FEBS vol. 293, No. 1,2, pp. 169-172 (1991).
Mulqueen et al., "Oral, anti-inflammatory activity of a potent, selective, protein kinase C inhibitor," Agents Action, 37:85-89 (1992).
Sarstedt et al., "Reactions with Indole Derivatives, ILVIII," Heterocycles, vol. 20, No. 3, pp. 469-476 (1983).
Toullec et al., "The Bisindolylmaleimide GF 109203X Is a Potent and Selective Inhibitor of Protein Kinase C.," J. Biol. Chem. vol. 266, No. 24, pp. 15771-15781 (1991).

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