Fused pyrrolecarboxamides; GABA brain receptor ligands

Details Fused pyrrolecarboxamides; GABA brain receptor ligands Fused pyrrolecarboxamides; GABA brain receptor ligands

2006-09-19

2006-09-19

Lambkin, Deborah C. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S419000

Reexamination Certificate

active

07109351

ABSTRACT:
Substituted pyrrolecarboxamide compounds are disclosed. These compounds are highly selective agonists, antagonists or inverse agonists for GABAAbrain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAAbrain receptors and are therefore useful in the diagnosis and treatment of anxiety, depression, Alzheimer's dementia, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory. Pharmaceutical compositions, including packaged pharmaceutical compositions, are further provided. Compounds of the invention are also useful as probes for the localization of GABAAreceptors in tissue samples.

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