Fused pyridazine derivative compounds and drugs containing...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C544S237000, C544S116000, C514S248000

Reexamination Certificate

active

07402580

ABSTRACT:
Fused pyridazine derivatives represented by formula (I) or pharmaceutically acceptable salts thereof (wherein each symbol has the meaning as defined in the specification.).Because of inhibiting poly(ADP-ribose)polymerase, the compounds represented by formula (I) are useful as preventives and/or remedies for various ischemic diseases (in brain, cord, heart, digestive tract, skeletal muscle, retina, etc.), inflammatory diseases (inflammatory bowel disease, multiple cerebrosclerosis, arthritis, etc.), neurodegenerative diseases (extrapyramidal disorder, Alzheimer's disease, muscular dystrophy, lumbar spinal canal stenosis, etc.), diabetes, shock, head trauma, renal failure, hyperalgesia, etc. Moreover, these compounds are useful as agents against retroviruses (HIV etc.), sensitizers in treating cancer and immunosuppressants.

REFERENCES:
patent: 2005/0080096 (2005-04-01), Ishida et al.
patent: 1148053 (2000-01-01), None
patent: WO 00/44726 (2000-01-01), None
Szabo et al. Montashefte fur Chemie, 133, 241-248 (2002).
Migliara, Onofrio; Petruso, et al., Hydrazinolysis of 4-Acyl and 4-Ethoxycarbonyl-3H-imidazo[1,5-b] pyridazine-5,7-(6H)diones: 8-Oxo-7, 8-dioxo-1,4,5,6,7,8-Hexahydropyridazino[4,5-c]pyridazine Derivatives, J. Heterocyclic Chem., May 1980, vol. 17, pp. 529-531.
Chem.abstr., vol. 65 (1966), the abstract No. 13692g, W.E.Hahn, et al., Reactions of dimercaptomaleic acid derivatives. IV. Synthesis of some bicyclic systems containing 1,4-dithiin ring, Lodz. Towarz. Nauk, Wydzial III, Acta. Chim. (1965), 10, 31-8.

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