Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2008-07-22
2008-07-22
Habte, Kahsay T (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S237000, C544S116000, C514S248000
Reexamination Certificate
active
07402580
ABSTRACT:
Fused pyridazine derivatives represented by formula (I) or pharmaceutically acceptable salts thereof (wherein each symbol has the meaning as defined in the specification.).Because of inhibiting poly(ADP-ribose)polymerase, the compounds represented by formula (I) are useful as preventives and/or remedies for various ischemic diseases (in brain, cord, heart, digestive tract, skeletal muscle, retina, etc.), inflammatory diseases (inflammatory bowel disease, multiple cerebrosclerosis, arthritis, etc.), neurodegenerative diseases (extrapyramidal disorder, Alzheimer's disease, muscular dystrophy, lumbar spinal canal stenosis, etc.), diabetes, shock, head trauma, renal failure, hyperalgesia, etc. Moreover, these compounds are useful as agents against retroviruses (HIV etc.), sensitizers in treating cancer and immunosuppressants.
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Chem.abstr., vol. 65 (1966), the abstract No. 13692g, W.E.Hahn, et al., Reactions of dimercaptomaleic acid derivatives. IV. Synthesis of some bicyclic systems containing 1,4-dithiin ring, Lodz. Towarz. Nauk, Wydzial III, Acta. Chim. (1965), 10, 31-8.
Kamanaka Yoshihisa
Kamoshima Wataru
Seko Takuya
Takahashi Shinya
Takeuchi Jun
Habte Kahsay T
Ono Pharmaceutical Co. Ltd.
Sughrue & Mion, PLLC
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