Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1995-06-02
1997-01-28
Bernhardt, Emily
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
549 51, 549 57, C07D49504
Patent
active
055979181
ABSTRACT:
A fused pyridazine compound of the formula ##STR1## wherein each symbol is as defined in the description. The compounds of the present invention are useful as anxiolytic agents which selectively act on anxiety because of having less side effects (e.g. muscle-relaxation, sedation or interaction with alcohol/barbiturates).
REFERENCES:
patent: 4849421 (1989-07-01), Nakao et al.
patent: 4965264 (1990-10-01), Nakao et al.
patent: 5153194 (1992-10-01), Nakao et al.
patent: 5175162 (1992-12-01), Nakao et al.
I. Nakao et al, "Studies on the Synthesis of Condensed Pyridazine Derivatives. IV. Synthesis and Anxiolytic Activity of 2-Aryl-5,6-dihydro-(1)benzothiepino[5,4-c]pyridazin-3(2H)-ones and Related Compound" Chem. Pharm. Bull. 39(10) 2556-2563 (1991).
Morimoto Yasuto
Nakao Tohru
Takehara Shuzo
Tanaka Hiroshi
Bernhardt Emily
Yoshitomi Pharmaceutical Industries Ltd.
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