Fused pyrazine sulfoxide derivatives for use as antiulcer agents

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

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540599, 544350, 546118, H61K 31495, C07D40112, C07D40312, C07D24144

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active

051069768

ABSTRACT:
Novel sulfoxide derivatives having the formula (I) 5 or (V) show a gastric acid-secretion inhibitory effect: ##STR1## wherein each of R.sup.1 and R.sup.2 is hydrogen, lower alkyl, hydroxyalkyl, phenyl, phenylalkyl or cycloalkyl, R.sup.1 and R.sup.2 may form together with the adjacent N atom a heterocyclic group; each of R.sup.3, R.sup.4, R.sup.4a, R.sup.4b, R.sup.5, R.sup.6, and R.sup.7 is hydrogen, halogen, lower alkoxy, lower alkyl, trifluoromethyl, or fluorine atom-containing lower alkoxy; Y is CH or N; and Z is unsubstituted or substituted 2-pyridine or 2-aminophenyl.

REFERENCES:
patent: 4933342 (1990-06-01), Takahashi et al.
patent: 4933458 (1990-06-01), Okabe et al.
Ota et al., Chemical Abstracts, vol. 108, No. 186590 (1988), (Abstract for JP 62/209062, Sep. 14, 1987).

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