Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1998-06-18
2000-10-17
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142328, 51425216, 514267, 544115, 544249, 540575, A61K 31517, C07D23970, C07D40312
Patent
active
061332577
ABSTRACT:
Fused polycyclic 2-aminopyrimidines of formula (1) are described: wherein
REFERENCES:
patent: 3947467 (1976-03-01), Verge et al.
patent: 4012495 (1977-03-01), Schmiechen et al.
patent: 4015017 (1977-03-01), Gazave
patent: 4153713 (1979-05-01), Huth et al.
patent: 4193926 (1980-03-01), Schmiechen et al.
patent: 4303649 (1981-12-01), Jones
patent: 4548940 (1985-10-01), Ife
patent: 4694009 (1987-09-01), Hubele et al.
patent: 4788195 (1988-11-01), Torley et al.
patent: 4792561 (1988-12-01), Walker et al.
patent: 4876252 (1989-10-01), Torley et al.
patent: 4897396 (1990-01-01), Hubele
patent: 4921862 (1990-05-01), Walker et al.
patent: 4966622 (1990-10-01), Rempfler et al.
patent: 4971959 (1990-11-01), Hawkins
patent: 4987132 (1991-01-01), Mase et al.
patent: 5124455 (1992-06-01), Lombardo
patent: 5128358 (1992-07-01), Saccomano et al.
patent: 5159078 (1992-10-01), Rempfler et al.
patent: 5164372 (1992-11-01), Matsuo et al.
patent: 5175167 (1992-12-01), Zipperer et al.
patent: 5177085 (1993-01-01), Naef
patent: 5236918 (1993-08-01), Amschler et al.
patent: 5274002 (1993-12-01), Hawkins
patent: 5298511 (1994-03-01), Waterson
patent: 5326898 (1994-07-01), Chandraratna
patent: 5340827 (1994-08-01), Beeley et al.
patent: 5491147 (1996-02-01), Boyd et al.
patent: 5521184 (1996-05-01), Zimmermann
patent: 5550137 (1996-08-01), Beeley et al.
patent: 5580888 (1996-12-01), Warrellow et al.
patent: 5593997 (1997-01-01), Dow et al.
patent: 5608070 (1997-03-01), Alexander et al.
patent: 5622977 (1997-04-01), Warrellow et al.
patent: 5633257 (1997-05-01), Warrellow et al.
patent: 5674880 (1997-10-01), Boyd et al.
patent: 5691376 (1997-11-01), Caggiano et al.
patent: 5693659 (1997-12-01), Head et al.
patent: 5698711 (1997-12-01), Palfreyman
patent: 5716967 (1998-02-01), Kleinman
patent: 5723460 (1998-03-01), Warrellow et al.
patent: 5728708 (1998-03-01), Zimmermann
patent: 5739144 (1998-04-01), Warrellow et al.
patent: 5753663 (1998-05-01), Flippin et al.
patent: 5776958 (1998-07-01), Warrellow et al.
patent: 5780477 (1998-07-01), Head et al.
patent: 5780478 (1998-07-01), Alexander et al.
patent: 5786354 (1998-07-01), Warrellow et al.
patent: 5798373 (1998-08-01), Warrellow
patent: 5849770 (1998-12-01), Head et al.
patent: 5851784 (1998-12-01), Owens et al.
patent: 5859034 (1999-01-01), Warrellow et al.
patent: 5866593 (1999-02-01), Warrellow et al.
patent: 5891896 (1999-04-01), Warrellow et al.
patent: 5922741 (1999-07-01), Davis et al.
Kroon, A.P. et al., "SN(ANRORC) [addition nucleophilic ring opening-ring closing]-mechanism. XIII. SN(ANRORC) mechanism in the amination of 2-substituted 4-phenylpyrimidines with potassijm amide in liquid ammonia," Recl. Trav. Chim. Pays-Bas, 1974, 93(12), 325-328, Chemical Abstract No. 83:43256.
Ife, R.J., "Aminopyrimidinone derivaties as histamine H1-antagonists", CAPLUS Abstract No. 101:211163, Registry No. 92993-05-0, Jul. 4, 1984, 2 pages.
Ashton, "Selective Type IV Phosphodiesterase Inhibitors as Antiasthmatic Agents. The Syntheses and Biological Activities of 3-(Cyclopentyloxy)-4-methyoxybenzamides and Analogues", J. Med. Chem., 1994, 37, 1696-1703.
Beavo & Reifsnyder, "Primary Sequence of Cyclic Nucleotide Phosphodiesterase Isozymes and the Design of Selective Inhibitors" TIPS, 1990, 11, 150-155.
Buu-Hoi, N.P. et al., "Bromination of Some 1,2,2-Triarylethylenes" J. of Organic Chemistry, 1958, 1261-1263.
Buu-Hoi et al., "New Method for the Synthesis of .omega.,.omega.-Diarylacetophenones Aminated in the Aromatic Nucleus. Plynitration of Triarylethylenes", Chem. Abstr., 1964, 61(13), 16006h.
Bortolus et al., "cis-trans Isomerization of azastilbenes photosensitized by biacetyl", Mol. Photochem., 1970, 2(4), 311-321, CAPLUS accession No. 1971-434722, 2 pages.
Chan, A.C. et al., "The Role of Protein Tyrosine Kinases and Protein Tyrosine Phosphatases in T Cell Antigen Receptor Signal Transduction", Annu. Rev. Immunol., 1994, 12, 555-592.
Chatterjee, A. et al., "Total Synthesis of Ring-C Aromatic 18-Nor Steroid", Tetrahedron, 1980, 36, 2513-2519.
Chemical Abstracts, "Hypoglycemic Pharmaceuticals Containing Manzammide Derivatives", Chem. Abstr., 1983, 99(6), No. 43558Z.
Chemical Abstracts. Registry Handbook--Number Section. Printed Issues Columbus US *compounds with registry nos. 95992-21-5 (CARHBT(RN1) 1RN-1648RN(1985); 95971-60-1 (CARHBT(RN1) 1RN-1648RN(1985); 90053-37-5 (CARHBT(RM1) 1RM-1426RM(1984); 82668-18-6 (CARHBT(RK2) 1515RK-2955RK(1 982); 80395-25-1 (CARHBT(RK1) 1RK-1514RK(1982); 49610-49-3 (CARHBT(RC1) 1RC-1650RC(1974).
Chemical Abstracts, Registry No. 2732-15-2, prior to 1967, 1 page.
Chemical Abstracts, Registry No. 4593-13-9, prior to 1967, 1 page.
Clayton, S.E. et al., "Direct Aromatic tert-Butylation during the Synthesis of Thiochroman-4-ones", Tetrahedron, 1993, 49(4), 939-946.
Collins, R.F. et al., "The Chemotherapy of Schistosomiasis. Part IV. Some Ethers of 4-Amino-2-methoxyphenol", J. Chem. Soc., 1961, 1863-1879.
Daves, G.D. et al., "Pyrimidines. XIII. 2- and 6-Substituted 4-Pyrimidinecarboxylic Acids", J. Of Hev. Chem., 1964, 1, 130-133.
Degani, I. et al., "Cationi etero-aromatici Nota VI--Sintesi di alcuni derivati del perclorato di tiacromilio", Boll. Sci. Fac. Chim. Ind. Bologna, 1966, 24(2-3), 75-91 (English Summary Only).
Dietl, F. et al., "Chinone von Benzo-und Dibenzokronenethern", Synthesis, 1985, 626-631.
Dent et al., "Inhibition of eosinophil cyclic nucleotide PDE activity and opsonised zymosan-stimulated respiratory burst by `type IV`-selective PDE inhibitors", Br. J. Pharmacol., 1991, 103, 1339-1346.
El-Wakil et al., "Study of the proton magnetic resonance of methoxytamoxifen towards ortho-substitiution", Chem. Abstr., 1992, 116, 255248t.
Geissler, J.F. et al., "Thiazolidine-Diones. Biochemical and Biological Activity of a Novel Class of Tyrosine Protein Kinase Inhibitors", J. Of Biol. Chem., 1990, 265(36), 22255-22261.
Griffin, R.W. et al., "1-Methyl-7-halo-2-naphthalenecarboxylic Acid Derivatives", J. Organic Chem., 1964, 29(8), 2109-2116.
Gupta, A.S. et al., "Friedel-Crafts Condensation of Ethyl Allylmalonate with Anisole", Tetrahedron, 1967, 23, 2481-2490.
Hanks, S.K. et al., "The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification", FASEB J., 1995, 9, 576-596.
Hart et al., "Alkylation of Phenol with a Homoallylic Halide", J. Am. Chem. Soc., 1963, 85, 3269-3273.
Heaslip et al., "Phosphodiesterase-IV Inhibition, Respiratory Muscle Relaxation and Bronchodilation by WAY-PDA-641", J. Pharm. Exper. Ther., 1993, 268(2), 888-896.
Hirose et al., "Styrene Derivatives and Electrophotpgraphic Photoreceptor Containing Them", Chem. Abstr., 1993, 118, 136183z.
Ishikura, M. et al., "An Efficient Synthesis of 3-Heteroarylpyridines via Diethyl-(3-pyridyl)-borane" Synthesis, 1984, 936-938.
Iwashita, S. et al., "Signal Transduction System for Growth Factor Receptors Associated with Tyrosine Kinase Activity: Epidermal Growth Factor Receptor Singalling and Its Regulation", Cellular Signalling, 1992, 4(2), 123-132.
Johnson et al., "Identification of Retinoic Acid Receptor .beta. Subtype Specific Agonists", J. Med. Chem., 1996, 39(26), 5027-5030.
Kaiser et al., "Selective metalations of methylated pyridines and quinolines", J. Org. Chem., 1973, 38(1), 71-75, CAPLUS accession No. 1973-71853, 2 pages.
Karlsson et al., "T-Lymphocyte and Inflammatory Cell Research in Asthma", Joller, G. et al. (eds.), Academic Press, 1993, 323-347.
Kefalas, P. et al., "Signalling by the p60.sup.c-src Family of Protein-Tyrosine Kinases", Int. J. Biochem. Cell Biol., 1995, 27(6), 551-563.
Lehmann, J. et al., "Lactones; XIII. Grignard Reaction Followed by Phase-Transfer Oxidation: A Convenient Synthesis of .gamma.,.gamma.-Distributed .gamma.-Butyrolactones from .gamma.-Butyrolactone", Synthesis, 1987, 1064-1067 (English abstract only).
Lisle, H. et al., "IL-2-Induced Eosinophilia in the Rat Pleural Cavity: The Effect of Dexamethasone and Indomethacin", Br. J. Pharmacol. 1993, 108, 230.
Livi et al., "Cloning and Expression of cDNA for a Human Low-K.sub.m 3 Rolipram-sensitive Cyclic AMP Phosphodiesterase", Molecular and Cellular Bi
Batchelor Mark James
Davis Jeremy Martin
Davis Peter David
Moffat David Festus Charles
Celltech Therapeutics Limited
Raymond Richard L.
LandOfFree
Fused polycyclic 2-aminopyrimidine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Fused polycyclic 2-aminopyrimidine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fused polycyclic 2-aminopyrimidine derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-469069