Fused isoquinoline derivatives

Details Fused isoquinoline derivatives Fused isoquinoline derivatives

1976-08-09

1978-09-12

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260283S, 260289C, 424258, C07D47114, C07D49514, C07D51314

Patent

active

041137310

ABSTRACT:
Fused isoquinoline derivatives of the general formula ##STR1## wherein: A is a divalent radical selected from the groups ##STR2## wherein R.sub.3 and R.sub.4 each independently represents hydrogen, alkyl,, alkenyl, cycloalkyl, aryl, aralkyl, aralkenyl, cycloalkyl-alkyl or, taken together with the adjacent double bond, represent a cycloalkene containing from 5 to 8 carbon atoms or an aromatic nucleus;
R.sub.5 represents hydrogen, hydroxyl, alkyl, alkenyl, cycloalkyl, aryl, aralkyl, aralkenyl or cycloalkyl-alkyl;
Y is .dbd.O, .dbd.S or .dbd.NH;
X is --O--, --S-- or --NR.sub.6 -- wherein R.sub.6 represents hydrogen, alkyl, cycloalkyl, aryl, aralkyl or cycloalkyl-alkyl;
R.sub.1 and R.sub.2 each independently represents hydrogen, alkyl, phenyl, cycloalkyl, alkoxy, alkenyloxy, methylenedioxy, cycloalkoxy, halo or di-alkylamino or, taken together with the adjacent carbon atoms of the benzene ring, form a cycloalkenyl group containing 5 or 6 carbon atoms or an aromatic nucleus fused on the benzene ring. The compounds are essentially prepared through thermal cyclization of a compound of the formula ##STR3## wherein A, X, Y, R.sub.1 and R.sub.2 have the same meanings given before, with the proviso that R.sub.1 and R.sub.2 cannot simultaneously occupy both the ortho positions, B represents hydrogen, R represents an --OR.sub.7 or --NR.sub.8 R.sub.9 radical wherein R.sub.7 is alkyl, aryl or aralkyl and R.sub.8 and R.sub.9 each independently represents hydrogen, alkyl, aryl, aralkyl, or taken together with the adjacent nitrogen atom represent a heterocyclic saturated radical of 5 or 6 atoms which may contain a further hetero-atom selected from oxygen and nitrogen, or the symbols B and R taken together represent a further bond between the adjacent carbon and nitrogen atoms.

REFERENCES:
patent: 3630745 (1971-12-01), Beavers et al.
patent: 3644366 (1972-02-01), Jeanmart et al.
patent: 3663551 (1972-05-01), Deryckere et al.
Goodman et al, The Pharmacological Basis of Therapeutics (1965) pp. 37-43.
Bailey et al., Chemical Abstracts 51 417a (1957).
Ried et al., Chemical Abstracts, 64, 695a (1966).
Mohunta et al., J. Chem. Soc. (1934), pp. 1263-1264.
Winters et al., Chemical Abstracts, vol. 84, 43,930e (1976) of paper in Tetrahedron Letters (44) 3877-3878 (1975).

Affiliated with

Also associated with

Rating

Fused isoquinoline derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fused isoquinoline derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fused isoquinoline derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2383839