Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Patent
1996-08-12
1999-04-06
Bernhardt, Emily
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
544295, 544363, 544364, 546167, 546175, 546200, 5462767, 548441, 548448, C07D40312, C07D40314, C07D40112, C07D40114
Patent
active
058920412
ABSTRACT:
Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof wherein: ##STR2## represents an aromatic or alicyclic ring; R.sub.1 and R.sub.2 are the same or different and represent hydrogen, C.sub.1 -C.sub.6 alkyl, halogen, hydroxy, amino, cyano, nitro, trifluoromethyl, trifluoromethoxy, C.sub.1 -C.sub.6 alkoxy, --O.sub.2 CR', --NHCOR', --COR', --SO.sub.m R', where R' is C.sub.1 -C.sub.6 alkyl and wherein m is 0, 1 or 2; or
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Murray, P. John, et al., "A Novel Series of Arylpiperazines With High Affinity and Selectivity For The Dopamine D.sub.3 Receptor," Bioorg. & Med. Chem. Let., 5(3), 219-222 (1995).
Sokoloff, Pierre, et al., "Molecular cloning and characterization of a novel dopamine receptor (D.sub.3) as a target for neuroleptics," Nature, 347, 146-151 (Sep. 13, 1990).
Wasley Jan William Francis
Yuan Jun
Bernhardt Emily
Neurogen Corporation
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