Fused indazole compounds

Details Fused indazole compounds Fused indazole compounds

2008-06-24

2008-06-24

Anderson, Rebecca L (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S212050, C514S215000, C514S405000, C548S358100, C548S358500, C540S555000, C540S546000, C540S578000

Reexamination Certificate

active

07390797

ABSTRACT:
The present invention provides a novel fused indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them.Wherein Z11and Z12each independently represent a carbonyl group, a methylene group, etc.;represents a double bond or a single bond; R1arepresents a hydrogen atom, etc.; the ring A represents a benzene ring, a naphthalene ring or a 5- to 10-membered aromatic heterocyclic ring, etc.; and R2a, R2band R2ceach independently represent (1) a hydrogen atom, (2) a halogen atom, (3) a nitro group, etc.

REFERENCES:
patent: 4013672 (1977-03-01), Hoehn
patent: WO-00/08139 (2000-04-01), None
patent: WO-00/18407 (2000-04-01), None
patent: WO-00/35906 (2000-06-01), None
patent: WO-00/35921 (2000-06-01), None
patent: WO-01/12609 (2001-02-01), None
patent: WO-02/10137 (2002-02-01), None
patent: WO-02/066450 (2002-08-01), None
patent: WO-02/083648 (2002-10-01), None
O'Neill, Luk A. J. Targeting signal transduction as a strategy to treat inflammatory diseases, Nature Reviews. Drug Discovery. London: Jul. 2006. vol. 5, Iss. 7; p. 549.
Kyriakis et al., Nature, vol. 369, pp. 156-160, (1994).
Xia et al., Science, vol. 270, pp. 1326-1331, (1995).
Pulverer et al., Nature, vol. 353, pp. 674, (1995).
Mohit et al., Neuron, vol. 14, pp. 67-78, (1995).
Kuan et al., Neuron, vol. 22, pp. 667-676, (1999).
Sabapathy et al., J. Exp. Med., vol. 193, pp. 317-328, (2001).
Yang et al., Nature, vol. 389, pp. 865-870, (1997).
Smale et al, Experimental Neurology, vol. 133, pp. 225-230, (1995).
Mochizuki et al., Journal of Neurological Sciences, vol. 137, pp. 120-123, (1996).
Zhu et al., J. Neurochem., vol. 76, pp. 435-441, (2001).
Hollins et al., Journal of Heterocyclic Chemistry, vol. 16, No. 4, pp. 681-683, (1979).

Affiliated with

Also associated with

Rating

Fused indazole compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fused indazole compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fused indazole compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2810634