Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-02-25
2008-05-27
Murray, Jeffrey H (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C540S476000
Reexamination Certificate
active
07378426
ABSTRACT:
Disclosed are fused heterotricyclic compounds of the following formula I,or an enantiomer, diastereomer, tautomer or pharmaceutically acceptable salt thereof, wherein one of A ring or C ring is a 5-7 membered unsaturated heterocyclic ring. The disclosed compounds are useful as inhibitors of 17β-hydroxysteroid dehydrogenase 3 (17β-HSD3). Also disclosed are methods of using such compounds in the treatment of hormone sensitive diseases such as prostate cancer, and pharmaceutical compositions comprising such compounds.
REFERENCES:
patent: 3336293 (1967-08-01), Cusic et al.
patent: 5514505 (1996-05-01), Limburg et al.
patent: 2004/0176324 (2004-09-01), Salvati et al.
patent: 2005/0191707 (2005-09-01), Lorenzi et al.
patent: 2005/0250753 (2005-11-01), Fink et al.
patent: 06234753 (1994-08-01), None
patent: 2001-247573 (2001-09-01), None
patent: WO 9509858 (1995-04-01), None
King, et. al.; 2001; Encyclopedia of Reagents for Organic Synthesis; Palladium on Carbon; p. 1-12.
Scovill et. al.; 1980; Journal of Heterocyclic Chemistry; 17, 23, p. 23-27.
Schindler, et. al., Helvetica Chimica Acta (1966), 49(2), 985-9.
Gheiler, E. L., et al., Current concepts in androgen deprivation therapy—is there a “best” endocrine treatment?, World J. Urology., vol. 18, pp. 190-193, (2000).
Kambe, et al., “Intramolecular 1,3-Dipolar Cycloaddition Strategy for Enantioselective Synthesis of FR-900482 Analogues”, Organic Letters, vol. 3(16), pp. 2575-2578, (2001).
Cooper et al., Cyclic Amidines. Part IV. 5:6:22:23-Tetrahydro-5:11-endomethylenephenhomazines and Troger's Base, Journal of the Chemical Society, Abstracts, pp. 991-994, (1955).
PCT International Search Report (PCT/US05/06548) mailed Dec. 7, 2005.
PCT International Search Report (PCT/US05/06549) mailed Dec. 13, 2005.
U.S. Appl. No. 11/255,484, filed Oct. 21, 2005, Kick, et al.
Fink Brian E.
Gavai Ashvinikumar V.
Han Wen-Ching
Norris Derek J.
Tokarski John S.
Bristol--Myers Squibb Company
Greenblatt Gary D.
Murray Jeffrey H
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