Fused heterocyclic derivatives as PPAR modulators

Details Fused heterocyclic derivatives as PPAR modulators Fused heterocyclic derivatives as PPAR modulators

2008-04-09

2009-10-06

Anderson, Rebecca L (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S300000, C546S118000, C546S113000

Reexamination Certificate

active

07598266

ABSTRACT:
The present invention is directed to compounds represented by the following structural formula, Formula I:wherein:(a) X is selected from the group consisting of a single bond, O, S, S(O)2and N;(b) U is an aliphatic linker;(c) Y is selected from the group consisting of C, O, S, NH and a single bond;(d) E is C(R3)(R4)A or A and wherein(i) A is selected from the group consisting of carboxyl, tetrazole, C1-C6alkylnitrile, carboxamide, sulfonamide and acylsulfonamide;(e) B is selected from the group consisting of S, O, C, and N;(f) Z is selected from the group consisting of N and C; with the proviso that when B is C then Z is N.

REFERENCES:
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Byrn et al. Solid-State Chemistry of Drugs, 2d, Chapter 11 Hydrates and Solvates, 233-247, 233.
Rami, H.K., et al, “Synthetic ligands for PPAR gamma—review of patent literature 1994-1999”, Expert Opinion Ther. Patents, 2000, 10(5):623-634.

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