Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2005-03-03
2010-06-08
Jiang, Shaojia Anna (Department: 1623)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S122000, C514S023000
Reexamination Certificate
active
07732596
ABSTRACT:
The present invention provides nitrogen-containing fused cyclic derivatives represented by the following general formula or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, postprandial hyperglycemia, impaired glucose tolerance, diabetic complications or obesity, in the formula one of R1and R4represents a group represented by the following general formula (S) (in which R5and R6represent H, OH, a halogen atom, etc.; Q represents an alkylene group etc.; and ring A represents an aryl group etc.), and the other represents H, OH, an amino group, etc.; R2and R3represent H, OH, an amino group, a halogen atom, and an optionally substituted alkyl group, etc.; A1represents O, S, etc.; A2represents CH or N; G represents a group represented by the following general formula (G-1) or (G-2) (E1represents H, F or OH; and E2represents H, F, a methyl group, etc.), and pharmaceutical compositions comprising the same, and pharmaceutical uses thereof.
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Fujikura Hideki
Fushimi Nobuhiko
Isaji Masayuki
Jiang Shaojia Anna
Kissei Pharmaceutical Co. Ltd.
Lau Jonathan S
Sughrue & Mion, PLLC
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