Fused [d]pyridazin-7-ones

Details Fused [d]pyridazin-7-ones Fused [d]pyridazin-7-ones

2007-06-21

2010-06-08

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S234000

Reexamination Certificate

active

07732447

ABSTRACT:
The present invention is directed to fused [d]pyridazin-7-ones. The invention is also directed to methods for making and using the fused [d]pyridazin-7-ones. In particular, the compounds of the present invention may be effective in the treatment of diseases or disease states related to the activity of VEGFR2, MLK1 and CDK5 enzymes, including, for example, angiogenic disorders and neurodegenerative diseases.

REFERENCES:
patent: 0 512 817 (1997-02-01), None
patent: 1 002 535 (2000-05-01), None
patent: 08113574 (1996-05-01), None
patent: WO 03/022849 (2003-03-01), None
patent: WO 2004/035580 (2004-04-01), None
Nelkin, Annual rept. Jan. 1-Dec. 31, 2006, Johns Hopkins Univ Balt Md.
Feletar, et al., Drug Discov. Today: Disease Mechan., vol. 5, # 1, Spring 2008, e47-e54.
Nishiguchi, et al., Investigative Ophthalmol. & Vis. Sci., 2007;48:4315-4320.
Edirisinghe, et al., The FASEB Journal, 2008;22:2297-2310.
Dajka-Halasz et al.,Tetrahedron 60, 2004, pp. 2283-2291.
Monge et al.,An Real Acad. Farm., 1985, 51, pp. 485-493.
Monge et al.,Synthesis, 1984, pp. 160-161.
Kogan et al.,Khimiko-Farmatsevticheskii Zhurnal, 1974, 8(4), pp. 23-26.
Kogan et al.,Khimiya Geterotsiklicheskikh Soedinenii, 1973, 12, pp. 1654-1658.
Kogan et al.,Khimiya Geterotsiklicheskikh Soedinenii, 1976, 9, pp. 1218-1222.
Vlasova et al.,Khimiya Geterotsiklicheskikh Soedinenii, 1974, 6, pp. 784-787.
Staunton et al.,Journal of the Chemical Society, 1953, pp. 1889-1894.
El-Kashef et al.,ARKIVOC, 2003, (xiv), pp. 198-209.
Monge et al.,Acta Farm. Bonaerense, 1984 3(1), pp. 21-26.
Monge et al.,J. Heterocyclic Chem., 1984, 21, pp. 397-400.
Monge et al.,Anales de Quimica, 1975, 73, pp. 278-281.
Zhungietu et al.,Khimiya Geterotsiklicheskikh' Soedinenii, 1981, 8, pp. 1064-1066.
El-Kashef et al.,Molecules, 2004, 9, pp. 849-859.
Ghoneim et al., Bull. Fac. Pharm. Cairo Univ., 2001, 39, pp. 23-31.
Kurumi et al.,Heterocycles, 2000, 53(12), pp. 2809-2819.
Bare,J. Heterocyclic Chem., 1998, 35, pp. 1171-1186.
Monge et al.,Arch. Pharm., 1995, 328, pp. 689-698.
Stauch Slusher, et al.,J. Neural Transm, 1994, 97, pp. 175-185.
Guven et al.,Tetrahedron, 1993, 49, pp. 11145-11154.
Monge et al.,Arzneim. Forsch./Drug Res. 1993, 43(II), pp. 1175-1180.
Monge et al.,Eur. J. Med. Chem., 1991, 26, pp. 655-658.
Monge et al.,J. Med. Chem., 1991, 34, pp. 3023-3029.
Monge et al.,Journal of Pharmaceutical Science, 1982, 71(12), pp. 1406-1408.
Fernandez-Alvarez,J. Heterocyclic Chem., 1981, 18, pp. 1533-1536.
Hiremath, et al.,J. Indian Chem. Soc., 1981 LVII, pp. 782-784.
Kobayashi, et al.,Yakugaku Zasshi, 1971, 91(11) pp. 1164-1173.
Huntress et al.,Journal of the American Chemical Society, 1941, 63, pp. 2762-2766.

Affiliated with

Also associated with

Rating

Fused [d]pyridazin-7-ones does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fused [d]pyridazin-7-ones, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fused [d]pyridazin-7-ones will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4235501