Fused cycloaliphatic aminoalcohols

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

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544365, 544378, 544379, 544392, 544395, 544398, 546199, 546200, 546201, 546206, 546197, C07C 9314, C07D29508, C07D29518, C07D21158

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active

048269751

ABSTRACT:
The invention is concerned with fused cycloaliphatic aminoalcohols having pharmacological activity as anti-hypertensive, platelet aggregation inhibiting, hypolipemic, antianoxic and spasmolytic activity. The compounds have the generic formula ##STR1## in which the symbol n is an integer selected from 1 to 2, the compounds pertaining therefore to the indanol and tetralol series.

REFERENCES:
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patent: 4533745 (1985-08-01), McClure
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Chem. Ab. 84, 105281, 1976.
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Chem. Ab. 85(9), 62844, 1976.
Hagishita, S. et al., J. Chem. Soc., Perkin Trans. 1, 1984, (8), 1644-1669.
Rimek, H. et al., Justus Liebigs Ann. Chem. 1969, 726, 25-29.
Journal of Chemical Society C. 1967 (U.S.), R. I. Thrift: "Derivatives of 2-aminotetralin", pp. 288-293.
European Journal of Medicinal Chemistry, vol. 18, No. 3, 1983 Chatenay-Malabry (FR) J. G. Cannon: "Demi-rigid Ketone Congeners of Catecholemines", pp. 291-292.
Chemical Abstracts, vol. 85, No. 9, Aug. 30, 1976, Columbus, Ohio (U.S) see p. 542, abstract 62844s & JP, A, 75151853 (Takeda Chemical Industries, Ltd), Dec. 6, 1975.

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