Fused cyclic modulators of nuclear hormone receptor function

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C546S023000, C546S086000, C544S183000, C544S337000, C544S348000, C548S453000, C548S531000, C548S536000

Reexamination Certificate

active

07001911

ABSTRACT:
The invention pertains to fused cyclic compounds having the formula,wherein G is an optionally substituted aryl or heterocyclo, L is an optional linker, M is a bond, O, CR7R7′or NR10, and M′ is a bond or NR10, with the proviso that at least one of M or M′ must be a bond; E is C═Z2, CR7CR7′, SO2, P═OR2, or P═OOR2; Z1is O, S, NH, or NR6; Z2is O, S, NH, or NR6; A1is CR7or N; A2is CR7or N; Y is J—J′—J″ where J is (CR7R7′)n and n=0-3, J′ is a bond or O, S, S═O, SO2, NH, NR6, C═O, OC═O, NR1C═O, CR7R7′, C═CR8R8′, R2P═O, OPOOR2, OPO2, OSO2, C═N, NHNH, NHNR6, NR6NH, N═N, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo or aryl or substituted aryl, and J″ is (CR7R7′)n and n=0-3; W is CR7R7′—CR7R7′, CR8═CR8′, CR7R7′—C═O, NR9—CR7R7′, N═CR8, N═N, NR9—NR9′, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, or aryl or substituted aryl; and O, R2, R6, R7, R7′, R8, R8′, R9, R9′, and R10are as defined in the specification, to methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and to pharmaceutical compositions containing such compounds.

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