Fused compounds that inhibit vanilloid receptor subtype 1...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S412000, C548S241000, C548S469000

Reexamination Certificate

active

07375126

ABSTRACT:
The present invention discloses novel compounds of general formula (I)or a pharmaceutically acceptable salt or prodrug thereof (in which X1-X5, R5-R8b, Z1-Z2and Ar1are defined herein), a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain in mammals, and pharmaceutical compositions including those compounds and a process for making those compounds.

REFERENCES:
patent: 5656634 (1997-08-01), Chang et al.
patent: 6001860 (1999-12-01), Hamanaka
patent: 587180 (1994-03-01), None
patent: 1256574 (2002-11-01), None
patent: WO 98/50347 (1998-11-01), None
patent: WO03014064 (2003-02-01), None
patent: WO 03/055648 (2003-07-01), None
patent: WO03055484 (2003-07-01), None
patent: WO03070247 (2003-08-01), None
patent: WO03080578 (2003-10-01), None
patent: WO03097586 (2003-11-01), None
D. Landsiedel-Maier, “Structure Activity Relationship of Homonchiral 7-Substituted 1-Aminoindans as 5- HTIA Receptor Ligands,”Archiv Der Pharmazie, vol. 331, pp. 59-71, XP002296522 (1998).
J. Sterling, “Novel Dual Inhibitors of AchE and MAO,”Journal of Medicinal Chemistry, vol. 45, No. 24, pp. 5260-5279, XP002296523 (2002).
Prescott,Methods in Cell Biology, Academic Press, New York, N. Y. vol. XIV:33 et seq. (1976).
Berge et al.,J. Pharmaceutical Sciences66:1 et seq. (1977).
IUPAC 1974 Recommendation for Section E, Fundamental Sterochemistry, Pure App. Chem. 45:13-30 (1976).
R.P. Thummel, et al., “Polyaza Cavity-Shaped Molecules. Annelated Derivatives of 2-(2′-Pyridyl)-1,8-naphthyridine and 2,2′-Bi-1,8-naphthyridine”J. Org. Chem., vol. 49, pp. 2208-2212 (1984).
Hayes et al., “Cloning and Functional Expression of a Human Orthologue of Rat Vanilloid Receptor-1”,Pain88:205-215 (2000).
Collier et al., “The Abdominal Constriction Response and its Suppression by Analgesic Drugs in the Mouse,”Br. J. Pharmacol. Chemother. 32:295-310 (1968).
Pircio, et al., “A New Method for the Evaluation of Analgesic Activity using Adjuvant-Induced Arthritis in the Rat”Eur J. Pharmacol. vol. 31(2) pp. 207-215 (1975).
Nolano et al., “Topical Capsaicin in Humans: Parallel Loss of Epidermal Nerve Fibers and Pain Sensation,”Pain81:135-145 (1999).
Caterina et al., “The Vanilloid Receptor: A Molecular Gateway to the Pain Pathway,”Annu. Rev. Neurosci. 24:487-517 (2001).
Caterina et al., “Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor,”Science288:306-313 (2000).
Caterina et al., “The Capsaicin Receptor: A Heat-Activated Ion Channel in the Pain Pathway,”Nature389:816-824 (Oct. 23, 1997).
Fowler, “Intravesical Treatment of Overactive Bladder,”Urology 55(Supplement 5A) :60-64 (2000).
Davis et al., “Vanilloid Receptor-1 is Essential for Inflammatory Thermal Hyperalgesia,”Nature405:183-186 (2000).
Poste, et al., Prescott (Ed.) Methods in Cell Biology, Academic Press, New York, N.Y. vol. XIV:33 et seq. (1976).

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