Fused bicyclic metalloproteinase inhibitors

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C546S112000, C546S115000, C546S118000, C514S302000, C514S303000, C514S299000, C514S301000

Reexamination Certificate

active

06949651

ABSTRACT:
The present invention relates to fused bicyclic metalloproteinase inhibitors of the formulawherein A, B, X, Y, and R1are as defined in the specification, and to pharmaceutical compositions and methods of treating arthritis, inflammation, cancer and other disorders.

REFERENCES:
patent: 4038396 (1977-07-01), Shen et al.
patent: 5284661 (1994-02-01), Morimoto et al.
patent: 5977132 (1999-11-01), Suzuki et al.
patent: 6001849 (1999-12-01), Elliott et al.
patent: 6008243 (1999-12-01), Bender et al.
patent: 6656932 (2003-12-01), Picard et al.
patent: 2002/0151555 (2002-10-01), Barvian et al.
patent: 2002/0151558 (2002-10-01), Andrianjara et al.
patent: 2002/0156061 (2002-10-01), Barvian et al.
patent: 2002/0156069 (2002-10-01), Picard et al.
patent: 2002/0161000 (2002-10-01), Barvian et al.
patent: 2002/0193377 (2002-12-01), Andrianjara et al.
patent: 2003/0004172 (2003-01-01), Harter et al.
patent: 2003/0078276 (2003-04-01), Andrianjara et al.
patent: 2003/0087924 (2003-05-01), Sorenson
patent: 2003/0130278 (2003-07-01), Gaudilliere et al.
patent: 2003/0144274 (2003-07-01), Bunker et al.
patent: 2003/0216402 (2003-11-01), Gaudilliere et al.
patent: 2003/0220355 (2003-11-01), Gaudilliere et al.
patent: 2004/0006077 (2004-01-01), Gaudilliere et al.
patent: 0 555 480 (1993-08-01), None
patent: 0 935 963 (1999-08-01), None
patent: 0 935 963 (1999-08-01), None
patent: 1 138 680 (2001-10-01), None
patent: WO 00/09485 (2000-02-01), None
patent: WO 01/12611 (2001-02-01), None
patent: WO 01/028993 (2001-04-01), None
patent: WO 01/028993 (2001-04-01), None
patent: WO 01/63244 (2001-08-01), None
patent: WO 02/34726 (2002-05-01), None
patent: WO 02/34726 (2002-05-01), None
patent: WO 02/34753 (2002-05-01), None
patent: WO 02/34753 (2002-05-01), None
patent: WO 02/064080 (2002-08-01), None
patent: WO 02/064080 (2002-08-01), None
patent: WO 02/064547 (2002-08-01), None
patent: WO 02/064547 (2002-08-01), None
patent: WO 02/064568 (2002-08-01), None
patent: WO 02/064571 (2002-08-01), None
patent: WO 02/064572 (2002-08-01), None
patent: WO 02/064578 (2002-08-01), None
patent: WO 02/064595 (2002-08-01), None
patent: WO 02/064598 (2002-08-01), None
patent: WO 02/064599 (2002-08-01), None
patent: WO 03/032999 (2003-04-01), None
patent: WO 03/033478 (2003-04-01), None
patent: WO 03/076417 (2003-09-01), None
patent: WO 03/076417 (2003-09-01), None
patent: WO 04/000322 (2003-12-01), None
Kramberger et al. Journal of Heterocyclic Chemistry (1975), 12: 337-342.
U.S. Appl. No. 10/071,032, filed Feb. 8, 2002, Dyer et al.
U.S. Appl. No. 10/634,531, filed Aug. 5, 2003, Johnson.
U.S. Appl. No. 10/634,709, filed Aug. 5, 2003, Bunker et al.
U.S. Appl. No. 10/634,473, filed Aug. 5, 2003, Bunker et al.
U.S. Appl. No. 10/634,289, filed Aug. 5, 2003, Bunker et al.
U.S. Appl. No. 10/634,180, filed Aug. 5, 2003, Bunker et al.
U.S. Appl. No. 10/634,712, filed Aug. 5, 2003, Hicks et al.
U.S. Appl. No. 10/634,181, filed Aug. 5, 2003, Li.
U.S. Appl. No. 10/634,489, filed Aug. 5, 2003, Roark.
U.S. Appl. No. 10/634,420, filed Aug. 5, 2003, Roark.
U.S. Appl. No. 10/634,716, filed Aug. 5, 2003, Nahra et al.
U.S. Appl. No. 10/634,288, filed Aug. 5, 2003, O'Brien.
U.S. Appl. No. 10/634,717, filed Aug. 5, 2003, Nahra et al.
U.S. Appl. No. 10/634,177, filed Aug. 5, 2003, Wilson.
U.S. Appl. No. 10/634,290, filed Aug. 5, 2003, Wilson.
U.S. Appl. No. 10/634,182, filed Aug. 5, 2003, Li.
U.S. Appl. No. 10/634,419, filed Aug. 5, 2003, Hicks et al.
U.S. Appl. No. 10/634,713, filed Aug. 5, 2003, Picard.
U.S. Appl. No. 10/634,225, filed Aug. 5, 2003, Picard et al.
U.S. Appl. No. 10/634,718, filed Aug. 5, 2003, Ortwine.
U.S. Appl. No. 10/739,261, filed Dec. 18, 2003, Bunker et al.
Billinghurst, et al., Comparison of the Degradation of Type II Collagen and Proteoglycan in Nasal and Articular Cartilages Induced by Interleukin-1 and the Selective Inhibition of Type II Collagen Cleavage by Collagenase, Arthritis & Rheumatism, 2000; 43(3): 664-672.
Billinghurst, et al., Enhanced Cleavage of Type II Collagen by Collagenases in Osteoarthritic Articular Cartilage, J. Clin Invest., 1997; 99(7): 1534-1545.
Chen, et al., Structure-Based Design of a Novel, Potent, and selective Inhibitor for MMP-13 Utilizing NMR Spectroscopy and Computer-Aided Molecular Design, J. Am. Chem. Soc., 2000; 122: 9648-9654.
Dahlberg, et al., Selective Enhancement of Collagenase-mediated Cleavage of Resident Type II Collagen in Cultured Osteoarthritic Cartilage and Arrest with a Synthetic Inhibitor that Spares Collagenase 1 (Matrix Metalloproteinase2), Arthritis & Rheumaatism, 2000; 43(3): 673-682.
Gilis, et al., 1H-tetrazol-5-yl derivativesof chemotherapeutic agents of the nalidizic acid type, Eur. J. Med. Chem., 1980; 15(6):499-502.
Harris, The Oxidation of N-(2-Pyridyl) Thioureas. The Synthesis of [1.2.4] Thaiadiazolo [2,3-a] Pyridinium Salts, Aust. J. Chem., 1972;25(5): 993-1001.
Hirota, et al., Novel Synthesis of Pyrido[3,4-d]pyrimidines, Pyrido[2,3-d]pyrimidines, and Quinazolines via Palladium-catalyzed Oxidative Coupling, Heterocycles, 1994; 37(1): 563-570.
Lee, et al. Reactions of 3-Methylamino-5phenylthiophene with a,B-Unsaturated Esters and a, B-Unsaturated Nitriles, Journal of Heterocyclic Chemistry, 2000; 37: 363-372.
Lovejoy, et al., Crystal structures of MMP-1 AND -13 reveal the structural basis for selectivity of collagenase inhibitors, Nature Structural Biology, 1999; 6(3): 217-221.
Mitchell, et al., Cloning, Expression, and Type II Collagenolytic Activity of Matrix Metaloproteinase-13 from Human Osteoarthritic, Cartilage, J. Clin. Invest., 1996; 97: 761-768.
Moy, et al., High-resolution Solution Structure of the Catliytic Fragment of Human Collagenase-3 (MMP-3) Complexed with a Hydroxamic Acid Inhibitor, J. Mol. Biol., 2000; 302: 671-689.
Neuhold, et al., Postnatal expression in Hyaline carilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice, J. Clin. Invest., 2001; 107(1): 35-44.
Office Action mailed Jun. 16, 2003 in U.S. Appl. No. 10/264,764.
Search Report from PCT/IB03/03523.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Fused bicyclic metalloproteinase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fused bicyclic metalloproteinase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fused bicyclic metalloproteinase inhibitors will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3451259

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.