Fused-bicyclic lactams as interleukin-1.beta. converting enzyme

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514214, 514221, 514299, 514306, 514248, 5142272, 540567, 540593, 540460, 540461, 544 47, 544235, 546138, 546183, A61K 3155, C07D48704, C07D51304, C07D47104

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active

056397453

ABSTRACT:
Disclosed are compounds, compositions and methods for inhibiting interleukin-1.beta. protease activity. The compounds, bicyclic derivatives of aldehydes and .alpha.-substituted methyl ketones, have the formula (A) set out herein.

REFERENCES:
patent: 4341781 (1982-07-01), Hassall et al.
patent: 4399136 (1983-08-01), Hassall et al.
patent: 4988771 (1991-01-01), Angebauer et al.

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