Fused benzeneoxyacetic acid derivatives

Details Fused benzeneoxyacetic acid derivatives Fused benzeneoxyacetic acid derivatives

1998-10-07

1999-10-05

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 95, 514 89, 546269, 5462724, 548255, 5482622, A61K 31415, C07D24904, C07D24900

Patent

active

059624396

ABSTRACT:
Fused benzeneoxyacetic acid derivatives of the formula (I): ##STR1## or salts thereof possess an agonistic effect on the PGI.sub.2 receptor and thus are useful for preventing and/or treating thrombosis, arteriosclerosis, ischemic heart diseases, gastric ulcer and hypertension. A, B, D, and R.sup.1 are as defined in the specification.

REFERENCES:
patent: 4349684 (1982-09-01), Lautenschalger et al.
patent: 4367235 (1983-01-01), Ross et al.
patent: 4492708 (1985-01-01), Spitzer
patent: 4956379 (1990-09-01), Meanwell
patent: 5011851 (1991-04-01), Meanwell
patent: 5389666 (1995-02-01), Hamanaka et al.
patent: 5589426 (1996-12-01), Hamanaka et al.
patent: 5589496 (1996-12-01), Hamanaka et al.
S. Moncada et al., "An enzyme isolated . . . platelet aggregation" Nature 263:663-665 (1976).
R. Gryglewski et al., "Arterial Walls . . . prostaglandin endoperoxides" Prostaglandins 12(5):685-713 (1976).
R. Johnson et al., "The Chemical . . . prostaglandin X (Prostacyclin)" Prostaglandins 12(6):915-928 (1976).
R.R. Gorman et al., "Modulation of . . . prostacyclin (PGX)" Prostaglandins 13(3):377-388 (1977).
Chemical & Engineering News, Dec. 20, 1976, pp. 17-19.
R.L. Jones et al., "Antagonism of . . . and Guinea-Pig Trachea" Br. J. Pharmac. 76:423-438 (1982).
R. Armstrong et al., "Competitive antagonism . . . human platelets" Br. J. Pharmac. 84:595-607 (1985).
J. Merritt et al., "Octimibate, a potent . . . prostacyclin receptor" Br. J. Pharmac. 102:251-259 (1991).
J. Merritt et al., "Primate vascular responses . . . prostacyclin receptor" Br. J. Pharmac. 102:260-265 (1991).

Affiliated with

Also associated with

Rating

Fused benzeneoxyacetic acid derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fused benzeneoxyacetic acid derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fused benzeneoxyacetic acid derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1171575